{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:06:43Z","timestamp":1790287603863,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T00:00:00Z","timestamp":1386028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Dopamine is a neurotransmitter that mediates the reward value of food. Methylphenidate (MPH) selectively binds and inhibits the dopamine transporter, thus increasing brain dopamine levels shortly after oral administration. This investigation studied whether a single dose of MPH decreases energy intake (EI) in obese teenagers compared to placebo (P).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study used a single\u2010blind, placebo\u2010controlled, within subject design. Teenagers with body mass index (BMI) \u226595th percentile underwent two identical meal tests (P or MPH) after a 10 h fast in random order. Food was weighed before and after the meals, and EI was calculated as energy content\/gram of consumed foods. Total and macronutrient EI (mean \u00b1 SD) were analyzed by Mann\u2013Whitney <jats:italic>U<\/jats:italic> and Wilcoxon tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two subjects (15 females, 7 males) completed the study. Participants were 13.4 \u00b1 2.2 years old and had BMI 34.9 \u00b1 10.7 kg\/m\u00b2. EI from fat (167 vs. 203 kcal, <jats:italic>P<\/jats:italic> = 0.03) and carbohydrates (311 vs. 389 kcal, <jats:italic>P<\/jats:italic> = 0.04) was decreased for MPH compared to P meals, with a trend in decreased total EI (545 vs. 663 kcal, <jats:italic>P<\/jats:italic> = 0.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A single dose of MPH decreases EI from fat and carbohydrates in obese adolescents. This effect underscores the importance of central dopamine signaling on eating behavior.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.20574","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T14:35:44Z","timestamp":1373380544000},"page":"781-785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Methylphenidate decreases fat and carbohydrate intake in obese teenagers"],"prefix":"10.1002","volume":"22","author":[{"given":"N.","family":"Danilovich","sequence":"first","affiliation":[{"name":"Women and Children's Hospital of Buffalo, Department of Pediatrics, School of Medicine and Biomedical Sciences University at Buffalo Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.D.","family":"Mastrandrea","sequence":"additional","affiliation":[{"name":"Women and Children's Hospital of Buffalo, Department of Pediatrics, School of Medicine and Biomedical Sciences University at Buffalo Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Cataldi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Quattrin","sequence":"additional","affiliation":[{"name":"Women and Children's Hospital of Buffalo, Department of Pediatrics, School of Medicine and Biomedical Sciences University at Buffalo Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.06.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.6.5.601"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301348"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199937060-00002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.29"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024295422944"},{"key":"e_1_2_6_8_1","first-page":"993","article-title":"Association of attention\u2010deficit disorder and the dopamine transporter gene","volume":"56","author":"Cook EH","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2008.046"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-108X(199812)24:4<405::AID-EAT7>3.0.CO;2-D"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674370200601S05"},{"key":"e_1_2_6_12_1","first-page":"361","article-title":"Does the dopamine transporter protein allele predict growth hormone testing results or response to growth hormone therapy?","volume":"37","author":"Daniel M","year":"2010","journal-title":"Endocrinology"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.10.1325"},{"key":"e_1_2_6_14_1","first-page":"397","article-title":"Beneficial health effects of modest weight loss","volume":"16","author":"Goldstein DJ","year":"1992","journal-title":"Int J Obes Relat Metab Disord"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370120307"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.20574","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.20574","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.20574","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.20574","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.20574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T23:18:46Z","timestamp":1692314326000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.20574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,3]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1002\/oby.20574"],"URL":"https:\/\/doi.org\/10.1002\/oby.20574","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,3]]},"assertion":[{"value":"2012-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}