{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:12:38Z","timestamp":1787602358952,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1002\/oby.20624","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:32:07Z","timestamp":1381541527000},"page":"332-336","source":"Crossref","is-referenced-by-count":68,"title":["Epicardial fat thickness and nonalcoholic fatty liver disease in obese subjects"],"prefix":"10.1002","volume":"22","author":[{"given":"Gianluca","family":"Iacobellis","sequence":"first","affiliation":[{"name":"Division of Diabetes, Endocrinology and Metabolism, Department of Medicine; University of Miami Miller School of Medicine; Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Barbarini","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases; Foundation IRCCS S. Matteo; Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Letizia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialities; University of Rome Sapienza; Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Barbaro","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Section of Medical Pathophysiology; University of Rome Sapienza; Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,17]]},"reference":[{"key":"10.1002\/oby.20624-BIB0001|oby20624-cit-0001","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.tem.2011.07.003","article-title":"Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features","volume":"22","author":"Iacobellis","year":"2011","journal-title":"Trends Endocrinol Metab."},{"key":"10.1002\/oby.20624-BIB0002|oby20624-cit-0002","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/ncpcardio0319","article-title":"Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart","volume":"2","author":"Iacobellis","year":"2005","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"10.1002\/oby.20624-BIB0003|oby20624-cit-0003","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1210\/jc.2012-3190","article-title":"Cardiac steatosis associates with visceral obesity in nondiabetic obese men","volume":"98","author":"Gran\u00e9r","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/oby.20624-BIB0004|oby20624-cit-0004","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jhep.2008.06.012","article-title":"Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: a systematic review","volume":"49","author":"Sookoian","year":"2008","journal-title":"J Hepatol"},{"key":"10.1002\/oby.20624-BIB0005|oby20624-cit-0005","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.atherosclerosis.2012.06.005","article-title":"Nonalcoholic fatty liver disease is associated with subclinical atherosclerosis independent of obesity and metabolic syndrome in Asian Indians","volume":"223","author":"Thakur","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1002\/oby.20624-BIB0006|oby20624-cit-0006","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1161\/ATVBAHA.112.252957","article-title":"Nonalcoholic fatty liver disease is associated with atherosclerosis in middle-aged and elderly Chinese","volume":"32","author":"Huang","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1002\/oby.20624-BIB0007|oby20624-cit-0007","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/HCO.0b013e3283605fba","article-title":"Epicardial fat and vascular risk: a narrative review","volume":"28","author":"Katsiki","year":"2013","journal-title":"Curr Opin Cardiol"},{"key":"10.1002\/oby.20624-BIB0008|oby20624-cit-0008","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/oby.2007.50","article-title":"Relation of epicardial fat and alanine aminotransferase in subjects with increased visceral fat","volume":"16","author":"Iacobellis","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"10.1002\/oby.20624-BIB0009|oby20624-cit-0009","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/BF03346328","article-title":"Epicardial adipose tissue, hepatic steatosis and obesity","volume":"30","author":"Cikim","year":"2007","journal-title":"J Endocrinol Invest"},{"key":"10.1002\/oby.20624-BIB0010|oby20624-cit-0010","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/apt.12186","article-title":"Review article: the diagnosis of non-alcoholic fatty liver disease-availability and accuracy of non-invasive methods","volume":"37","author":"Festi","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1002\/oby.20624-BIB0011|oby20624-cit-0011","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.amjcard.2010.01.368","article-title":"Relation of echocardiographic epicardial fat thickness and myocardial fat","volume":"105","author":"Malavazos","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1002\/oby.20624-BIB0012|oby20624-cit-0012","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.echo.2009.10.013","article-title":"Echocardiographic epicardial fat: a review of research and clinical applications","volume":"22","author":"Iacobellis","year":"2009","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1002\/oby.20624-BIB0013|oby20624-cit-0013","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/bmj.292.6512.13","article-title":"Ultrasound scanning in the detection of hepatic fibrosis and steatosis","volume":"292","author":"Saverymuttu","year":"1986","journal-title":"Br Med J (Clin Res Ed)"},{"key":"10.1002\/oby.20624-BIB0014|oby20624-cit-0014","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/jgh.12106","article-title":"Non-alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: results of a US national survey in three ethnic groups","volume":"28","author":"Smits","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1002\/oby.20624-BIB0015|oby20624-cit-0015","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1517\/14656566.2011.629188","article-title":"Managing the combination of nonalcoholic fatty liver disease and metabolic syndrome","volume":"12","author":"Moscatiello","year":"2011","journal-title":"Expert Opin Pharmacother"},{"key":"10.1002\/oby.20624-BIB0016|oby20624-cit-0016","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.amjcard.2006.12.082","article-title":"Relation of subepicardial adipose tissue to carotid intima-media thickness in patients with human immunodeficiency virus","volume":"99","author":"Iacobellis","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1002\/oby.20624-BIB0017|oby20624-cit-0017","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1210\/jc.2003-030698","article-title":"Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk","volume":"88","author":"Iacobellis","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/oby.20624-BIB0018|oby20624-cit-0018","first-page":"234","article-title":"Metaanalysis of the relation of echocardiographic epicardial adipose tissue thickness and the metabolic syndrome","volume":"151","author":"Pierdomenico","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1002\/oby.20624-BIB0019|oby20624-cit-0019","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.echo.2011.09.018","article-title":"Epicardial adipose tissue relating to anthropometrics, metabolic derangements and fatty liver disease independently contributes to serum high-sensitivity C-reactive protein beyond body fat composition: a study validated with computed tomography disease","volume":"25","author":"Lai","year":"2012","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1002\/oby.20624-BIB0020|oby20624-cit-0020","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1210\/jc.2006-0584","article-title":"Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels","volume":"91","author":"Kankaanp\u00e4\u00e4","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/oby.20624-BIB0021|oby20624-cit-0021","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/hep.21983","article-title":"Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver","volume":"47","author":"Perseghin","year":"2008","journal-title":"Hepatology"},{"key":"10.1002\/oby.20624-BIB0022|oby20624-cit-0022","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.atherosclerosis.2011.03.026","article-title":"Circulating vaspin levels and epicardial adipose tissue thickness are associated with impaired coronary flow reserve in patients with nonalcoholic fatty liver disease","volume":"217","author":"Yilmaz","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1002\/oby.20624-BIB0023|oby20624-cit-0023","doi-asserted-by":"crossref","first-page":"698","DOI":"10.2174\/157016111797484152","article-title":"Katsiki N, Athyros VG, Karagiannis A, et al. Hyperuricaemia and non-alcoholic fatty liver disease (NAFLD): a relationship with implications for vascular risk?","volume":"9","year":"2011","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1002\/oby.20624-BIB0024|oby20624-cit-0024","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.metabol.2012.08.013","article-title":"Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: liver ultrasound data from the National Health and Nutrition Examination Survey","volume":"62","author":"Sirota","year":"2013","journal-title":"Metabolism"},{"key":"10.1002\/oby.20624-BIB0025|oby20624-cit-0025","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1161\/CIRCULATIONAHA.106.645614","article-title":"Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study","volume":"116","author":"McGavock","year":"2007","journal-title":"Circulation"},{"key":"10.1002\/oby.20624-BIB0026|oby20624-cit-0026","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.amjcard.2006.12.042","article-title":"Effects of weight loss after bariatric surgery on epicardial fat measured using echocardiography","volume":"99","author":"Willens","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1002\/oby.20624-BIB0027|oby20624-cit-0027","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.jacc.2012.06.016","article-title":"Effects of bariatric surgery on cardiac ectopic fat: lesser decrease in epicardial fat compared to visceral fat loss and no change in myocardial triglyceride content","volume":"60","author":"Gaborit","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1002\/oby.20624-BIB0028|oby20624-cit-0028","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1038\/oby.2008.251","article-title":"Substantial changes in epicardial fat thickness after weight loss in severely obese subjects","volume":"16","author":"Iacobellis","year":"2008","journal-title":"Obesity"},{"key":"10.1002\/oby.20624-BIB0029|oby20624-cit-0029","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1210\/jc.2009-1441","article-title":"Pioglitazone compared with metformin increases pericardial fat volume in patients with type 2 diabetes mellitus","volume":"95","author":"Jonker","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/oby.20624-BIB0030|oby20624-cit-0030","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1161\/CIRCULATIONAHA.108.803916","article-title":"Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus","volume":"19","author":"Meer","year":"2009","journal-title":"Circulation"},{"key":"10.1002\/oby.20624-BIB0031|oby20624-cit-0031","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/oby.2008.575","article-title":"Epicardial and pericardial fat: close, but very different","volume":"17","author":"Iacobellis","year":"2009","journal-title":"Obesity"},{"key":"10.1002\/oby.20624-BIB0032|oby20624-cit-0032","doi-asserted-by":"crossref","first-page":"730","DOI":"10.2337\/dc10-2083","article-title":"Inflammatory genes in epicardial fat contiguous with coronary atherosclerosis in the metabolic syndrome and type 2 diabetes: changes associated with pioglitazone","volume":"34","author":"Sacks","year":"2011","journal-title":"Diabetes Care"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.20624","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.20624","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/oby.20624\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T16:13:51Z","timestamp":1625415231000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.20624"}},"subtitle":["Epicardial Fat and Nonalcoholic Fatty Liver Disease"],"short-title":[],"issued":{"date-parts":[[2013,10,17]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"URL":"https:\/\/doi.org\/10.1002\/oby.20624","archive":["Portico"],"relation":{},"ISSN":["1930-7381"],"issn-type":[{"value":"1930-7381","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10,17]]}}}