{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:29:30Z","timestamp":1761895770195},"reference-count":41,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T00:00:00Z","timestamp":1384905600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>Although serious health concerns are associated with obesity, losing even 5% of body weight can produce clinically relevant effects. The initial goal of obesity management is usually a 5% to 10% weight reduction. Some people will sustain weight loss with changes in diet and exercise alone; however, these patients represent the minority, and a large percentage are unable to maintain weight loss over time.<\/jats:p><jats:p>Patients and providers often wish to intensify obesity treatment, and therefore interest in new medications has been considerable. Until recently, only two antiobesity medications have received Food and Drug Administration approval for long\u2010term use. In June and July of 2012, respectively, lorcaserin and combination phentermine\/topiramate extended\u2010release were approved for obesity therapy. The first section of this article reviews mechanisms, clinical trials, benefits and risks of available medications for treating obesity.<\/jats:p><jats:p>Bariatric surgery is the next step for patients with a body mass index of \u226540 kg\/m<jats:sup>2<\/jats:sup> or \u226535 kg\/m<jats:sup>2<\/jats:sup> with comorbidities, based on National Institutes of Health Clinical Guidelines. These procedures and their risks and benefits are reviewed in the second section. The final section presents common clinical scenarios with guidance for choosing among evidence\u2010based recommendations for developing optimal, individualized, long\u2010term strategies for patients with obesity.<\/jats:p>","DOI":"10.1002\/oby.20627","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:15:21Z","timestamp":1384992921000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Obesity consults\u2014comprehensive obesity management in 2013: Understanding the shifting paradigm"],"prefix":"10.1002","volume":"21","author":[{"given":"Robert F.","family":"Kushner","sequence":"first","affiliation":[{"name":"Northwestern Comprehensive Center on Obesity Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline M.","family":"Apovian","sequence":"additional","affiliation":[{"name":"Nutrition and Weight Management Center Boston Medical Center, Boston University School of Medicine, Obesity Research Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolic Research Division of Diabetes and Endocrinology, Scripps Clinic San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"issue":"2","key":"e_1_2_5_2_1","first-page":"51S","article-title":"evaluation, and treatment of overweight and obesity in adults","volume":"6","author":"Clinical guidelines on the identification","year":"1998","journal-title":"Obes Res."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05026"},{"key":"e_1_2_5_4_1","unstructured":"Phentermine [package insert]. 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