{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:43:53Z","timestamp":1791179033080,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T00:00:00Z","timestamp":1389225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the relationships between parameters of glucose and insulin metabolism and visceral and abdominal ectopic fat in youth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross sectional study of 50 children (24 females), 8\u201018 years old. Anthropometrics, body composition, blood\u2010work and visceral and ectopic fat by magnetic resonance imaging were assessed. Insulin secretion, insulin sensitivity and beta cell function were calculated from an oral glucose tolerance test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BMI <jats:italic>z<\/jats:italic>\u2010scores ranged between \u22121.3 and 4.5. The hepatic fat fraction (HFF) ranged between 0 and 36% and pancreatic fat fraction (PFF) between 0 and 14%. Visceral fat, HFF and PFF were associated with clinical and biochemical metabolic abnormalities, and correlated with markers of insulin sensitivity (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.60, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.64, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.48, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, respectively) insulin secretion (<jats:italic>r<\/jats:italic>\u2009=\u20090.55, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>r<\/jats:italic>\u2009=\u20090.57, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>r<\/jats:italic>\u2009=\u20090.41, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, respectively), and beta cell function (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.49, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.59, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.39, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Accumulations of pancreatic and hepatic fat have complementary clinical consequences in youth. While visceral and hepatic fat demonstrated a dominant effect, even relatively small degrees of pancreatic fat deposition may contribute to metabolic alterations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.20674","type":"journal-article","created":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T12:06:30Z","timestamp":1386158790000},"page":"1280-1286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Ectopic fat in youth: The contribution of hepatic and pancreatic fat to metabolic disturbances"],"prefix":"10.1002","volume":"22","author":[{"given":"Michal","family":"Cohen","sequence":"first","affiliation":[{"name":"Division of Endocrinology the Hospital for Sick Children and the University of Toronto  ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona","family":"Syme","sequence":"additional","affiliation":[{"name":"The Physiology and Experimental Medicine Program the Hospital for Sick Children and the University of Toronto  ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Deforest","sequence":"additional","affiliation":[{"name":"Division of Endocrinology the Hospital for Sick Children and the University of Toronto  ON Canada"},{"name":"Summer Research Program The Hospital for Sick Children  ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Wells","sequence":"additional","affiliation":[{"name":"The Physiology and Experimental Medicine Program the Hospital for Sick Children and the University of Toronto  ON Canada"},{"name":"Faculty of Kinesiology and Physical Education University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry","family":"Detzler","sequence":"additional","affiliation":[{"name":"The Physiology and Experimental Medicine Program the Hospital for Sick Children and the University of Toronto  ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Ling","family":"Cheng","sequence":"additional","affiliation":[{"name":"The Physiology and Experimental Medicine Program the Hospital for Sick Children and the University of Toronto  ON Canada"},{"name":"Department of Medical Biophysics and Medical Imaging University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"McCrindle","sequence":"additional","affiliation":[{"name":"Division of Cardiology the Hospital for Sick Children and the University of Toronto  ON Canada"},{"name":"Department of Pediatrics University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Hanley","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences University of Toronto Toronto ON 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