{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:23:27Z","timestamp":1792167807519,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["DK059630"],"award-info":[{"award-number":["DK059630"]}]},{"name":"NIH","award":["R01-DK092587"],"award-info":[{"award-number":["R01-DK092587"]}]},{"name":"HM"},{"name":"COBRE","award":["NIH P20-RR021945"],"award-info":[{"award-number":["NIH P20-RR021945"]}]},{"name":"CNRU","award":["NIH 1P30-DK072476"],"award-info":[{"award-number":["NIH 1P30-DK072476"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1002\/oby.20719","type":"journal-article","created":{"date-parts":[[2014,2,8]],"date-time":"2014-02-08T10:19:19Z","timestamp":1391854759000},"page":"1477-1484","source":"Crossref","is-referenced-by-count":61,"title":["Central mechanisms of adiposity in adult female mice with androgen excess"],"prefix":"10.1002","volume":"22","author":[{"given":"Kazunari","family":"Nohara","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Metabolism and Molecular Medicine; Northwestern University Feinberg School of Medicine; Chicago Illinois USA"},{"name":"Comprehensive Center on Obesity; Northwestern University Feinberg School of Medicine; Chicago Illinois USA"},{"name":"Department of Medicine; Northwestern University Feinberg School of Medicine; Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Laque","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, Louisiana State University System; Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Allard","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine; Tulane University Health Sciences Center, School of Medicine; New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"M\u00fcnzberg","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, Louisiana State University System; Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Mauvais-Jarvis","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Molecular Medicine; Northwestern University Feinberg School of Medicine; Chicago Illinois USA"},{"name":"Comprehensive Center on Obesity; Northwestern University Feinberg School of Medicine; Chicago Illinois USA"},{"name":"Department of Medicine; Northwestern University Feinberg School of Medicine; Chicago Illinois USA"},{"name":"Division of Endocrinology and Metabolism, Department of Medicine; Tulane University Health Sciences Center, School of Medicine; New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,19]]},"reference":[{"key":"10.1002\/oby.20719-BIB0001|oby20719-cit-0001","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/oby.2003.42","article-title":"Increased adiposity in female rhesus monkeys exposed to androgen excess during early gestation","volume":"11","author":"Eisner","year":"2003","journal-title":"Obes Res"},{"key":"10.1002\/oby.20719-BIB0002|oby20719-cit-0002","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.2527\/1997.7561504x","article-title":"Effects of prenatal androgenization and lactation on adipose tissue metabolism in finishing single-calf heifers","volume":"75","author":"Reiling","year":"1997","journal-title":"J Anim Sci"},{"key":"10.1002\/oby.20719-BIB0003|oby20719-cit-0003","doi-asserted-by":"crossref","first-page":"E262","DOI":"10.1152\/ajpendo.90208.2008","article-title":"Transient prenatal androgen exposure produces metabolic syndrome in adult female rats","volume":"295","author":"Demissie","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1002\/oby.20719-BIB0004|oby20719-cit-0004","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1172\/JCI1353","article-title":"Imprinting of female offspring with testosterone results in insulin resistance and changes in body fat distribution at adult age in rats","volume":"101","author":"Nilsson","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1002\/oby.20719-BIB0005|oby20719-cit-0005","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1210\/en.2007-0168","article-title":"A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome","volume":"148","author":"Manneras","year":"2007","journal-title":"Endocrinology"},{"key":"10.1002\/oby.20719-BIB0006|oby20719-cit-0006","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.1210\/en.2007-0305","article-title":"Postnatal testosterone exposure results in insulin resistance, enlarged mesenteric adipocytes, and an atherogenic lipid profile in adult female rats: comparisons with estradiol and dihydrotestosterone","volume":"148","author":"Alexanderson","year":"2007","journal-title":"Endocrinology"},{"key":"10.1002\/oby.20719-BIB0007|oby20719-cit-0007","doi-asserted-by":"crossref","first-page":"E1321","DOI":"10.1152\/ajpendo.00620.2012","article-title":"Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice","volume":"304","author":"Nohara","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1002\/oby.20719-BIB0008|oby20719-cit-0008","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1210\/en.2010-1288","article-title":"Early-life exposure to testosterone programs the hypothalamic melanocortin system","volume":"152","author":"Nohara","year":"2011","journal-title":"Endocrinology"},{"key":"10.1002\/oby.20719-BIB0009|oby20719-cit-0009","first-page":"157","article-title":"Body fat topography in women with androgen excess","volume":"12","author":"Evans","year":"1988","journal-title":"Int J Obes"},{"key":"10.1002\/oby.20719-BIB0010|oby20719-cit-0010","doi-asserted-by":"crossref","first-page":"9264","DOI":"10.1523\/JNEUROSCI.20-24-09264.2000","article-title":"Reduced rearing temperature augments responses in sympathetic outflow to brown adipose tissue","volume":"20","author":"Morrison","year":"2000","journal-title":"J Neurosci"},{"key":"10.1002\/oby.20719-BIB0011|oby20719-cit-0011","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1172\/JCI119532","article-title":"Receptor-mediated regional sympathetic nerve activation by leptin","volume":"100","author":"Haynes","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1002\/oby.20719-BIB0012|oby20719-cit-0012","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/387094a0","article-title":"Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline","volume":"387","author":"Thomas","year":"1997","journal-title":"Nature"},{"key":"10.1002\/oby.20719-BIB0013|oby20719-cit-0013","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0896-6273(00)81084-3","article-title":"From lesions to leptin: hypothalamic control of food intake and body weight","volume":"22","author":"Elmquist","year":"1999","journal-title":"Neuron"},{"key":"10.1002\/oby.20719-BIB0014|oby20719-cit-0014","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/oby.2006.75","article-title":"Dihydrotestosterone treatment results in obesity and altered lipid metabolism in orchidectomized mice","volume":"14","author":"Moverare-Skrtic","year":"2006","journal-title":"Obesity (Silver Spring)"},{"key":"10.1002\/oby.20719-BIB0015|oby20719-cit-0015","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/BF01140499","article-title":"Brown fat activity in fasted and refed rats","volume":"4","author":"Rothwell","year":"1984","journal-title":"Biosci Rep"},{"key":"10.1002\/oby.20719-BIB0016|oby20719-cit-0016","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1093\/jn\/120.12.1730","article-title":"Effects of fasting and refeeding on the level of uncoupling protein mRNA in rat brown adipose tissue: evidence for diet-induced and cold-induced responses","volume":"120","author":"Champigny","year":"1990","journal-title":"J Nutr"},{"key":"10.1002\/oby.20719-BIB0017|oby20719-cit-0017","first-page":"E226","article-title":"Leptin increases uncoupling protein expression and energy expenditure","volume":"273","author":"Scarpace","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1002\/oby.20719-BIB0018|oby20719-cit-0018","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1523\/JNEUROSCI.3223-10.2011","article-title":"Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits","volume":"31","author":"Zhang","year":"2011","journal-title":"J Neurosci"},{"key":"10.1002\/oby.20719-BIB0019|oby20719-cit-0019","doi-asserted-by":"crossref","first-page":"E148","DOI":"10.1152\/ajpendo.00225.2004","article-title":"Early changes in insulin secretion and action induced by high-fat diet are related to a decreased sympathetic tone","volume":"288","author":"Cruciani-Guglielmacci","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1002\/oby.20719-BIB0020|oby20719-cit-0020","first-page":"247","article-title":"Decreased norepinephrine turnover rate in the brown adipose tissue of pre-obese fa\/fa Zucker rats","volume":"19","author":"Blouquit","year":"1993","journal-title":"J Dev Physiol"},{"key":"10.1002\/oby.20719-BIB0021|oby20719-cit-0021","doi-asserted-by":"crossref","first-page":"17675","DOI":"10.1074\/jbc.M113.475343","article-title":"Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing","volume":"288","author":"Cakir","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1002\/oby.20719-BIB0022|oby20719-cit-0022","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cell.2005.08.035","article-title":"Divergence of melanocortin pathways in the control of food intake and energy expenditure","volume":"123","author":"Balthasar","year":"2005","journal-title":"Cell"},{"key":"10.1002\/oby.20719-BIB0023|oby20719-cit-0023","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/cne.10643","article-title":"Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tissue during cold exposure","volume":"460","author":"Cano","year":"2003","journal-title":"J Comp Neurol"},{"key":"10.1002\/oby.20719-BIB0024|oby20719-cit-0024","doi-asserted-by":"crossref","first-page":"12189","DOI":"10.1523\/JNEUROSCI.2336-11.2011","article-title":"Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance","volume":"31","author":"Enriori","year":"2011","journal-title":"J Neurosci"},{"key":"10.1002\/oby.20719-BIB0025|oby20719-cit-0025","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cmet.2007.02.004","article-title":"Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons","volume":"5","author":"Enriori","year":"2007","journal-title":"Cell Metab"},{"key":"10.1002\/oby.20719-BIB0026|oby20719-cit-0026","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1210\/en.2004-0726","article-title":"Region-specific leptin resistance within the hypothalamus of diet-induced obese mice","volume":"145","author":"Munzberg","year":"2004","journal-title":"Endocrinology"},{"key":"10.1002\/oby.20719-BIB0027|oby20719-cit-0027","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1097\/00001756-200112210-00027","article-title":"Are POMC neurons targets for sex steroids in the arcuate nucleus of the rat?","volume":"12","author":"Fodor","year":"2001","journal-title":"Neuroreport"},{"key":"10.1002\/oby.20719-BIB0028|oby20719-cit-0028","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/(SICI)1096-9861(19990823)411:2<346::AID-CNE13>3.0.CO;2-S","article-title":"Identification and characterization of estrogen receptor alpha-containing neurons projecting to the vicinity of the gonadotropin-releasing hormone perikarya in the rostral preoptic area of the rat","volume":"411","author":"Simonian","year":"1999","journal-title":"J Comp Neurol"},{"key":"10.1002\/oby.20719-BIB0029|oby20719-cit-0029","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/cne.902940107","article-title":"Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study","volume":"294","author":"Simerly","year":"1990","journal-title":"J Comp Neurol"},{"key":"10.1002\/oby.20719-BIB0030|oby20719-cit-0030","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1111\/j.1460-9568.2005.04515.x","article-title":"Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus","volume":"22","author":"Nakamura","year":"2005","journal-title":"Eur J Neurosci"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.20719","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.20719","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/oby.20719\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T15:29:12Z","timestamp":1625412552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.20719"}},"subtitle":["Mechanism of Adiposity in Androgenized Females"],"short-title":[],"issued":{"date-parts":[[2014,2,19]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"URL":"https:\/\/doi.org\/10.1002\/oby.20719","archive":["Portico"],"relation":{},"ISSN":["1930-7381"],"issn-type":[{"value":"1930-7381","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2,19]]}}}