{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:01:10Z","timestamp":1791295270421,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NHMRC (Australian)","award":["626977"],"award-info":[{"award-number":["626977"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of modulating pouch emptying (PE) and SI transit of glucose after Roux\u2010en\u2010Y gastric bypass (RYGB) on blood glucose, incretin hormones, glucose absorption and gastrointestinal (GI) symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten RYGB patients were studied twice in random order, receiving either a 150 ml glucose drink (200 kcal) or the same solution infused into the proximal Roux\u2010limb at 4 kcal\/min. Data were compared with 10 healthy volunteers who received a 4 kcal\/min duodenal infusion. PE, cecal arrival time (CAT), blood glucose, plasma 3\u2010<jats:italic>O<\/jats:italic>\u2010methylglucose (3\u2010OMG), insulin, glucose\u2010dependent insulinotropic polypeptide (GIP), and glucagon\u2010like peptide\u20101 (GLP\u20101), and GI symptoms were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In RYGB subjects, the glucose drink emptied very rapidly (PE <jats:italic>t<\/jats:italic>50\u2009=\u20093\u2009\u00b1\u20091 min) and intestinal glucose infusion was associated with higher blood glucose and plasma 3\u2010OMG, but lower plasma GLP\u20101, GIP, insulin, and GI symptoms than oral glucose (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and comparable to volunteers. In RYGB subjects, CAT correlated inversely with peak GLP\u20101 (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.73, <jats:italic>P<\/jats:italic>\u2009=\u20090.01), and plasma 3\u2010OMG correlated tightly blood glucose (<jats:italic>r<\/jats:italic>\u2009=\u20090.94, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After RYGB, reducing intestinal glucose delivery to 4 kcal\/min is associated with higher blood glucose, greater glucose absorption, lower incretin responses, and less GI symptoms, supporting rapid transit contribution to the exaggerated incretin responses and \u201cdumping symptoms\u201d.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.20791","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T13:06:25Z","timestamp":1400072785000},"page":"2003-2009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Rapid gastric and intestinal transit is a major determinant of changes in blood glucose, intestinal hormones, glucose absorption and postprandial symptoms after gastric bypass"],"prefix":"10.1002","volume":"22","author":[{"given":"Nam Q.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Level 7 Royal Adelaide Hospital North Terrace Adelaide South Australia 5000 Australia"},{"name":"Discipline of Medicine University of Adelaide, Royal Adelaide Hospital Level 6 Eleanor Harrold Building, North Terrace Adelaide South Australia 5000 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara L.","family":"Debreceni","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Level 7 Royal Adelaide Hospital North Terrace Adelaide South Australia 5000 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna E.","family":"Bambrick","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Level 7 Royal Adelaide Hospital North Terrace Adelaide South Australia 5000 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Bellon","sequence":"additional","affiliation":[{"name":"Nuclear Medicine PET and Bone Densitometry Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Wishart","sequence":"additional","affiliation":[{"name":"Discipline of Medicine University of Adelaide, Royal 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Discipline of Medicine University of Adelaide, Royal Adelaide Hospital Level 6 Eleanor Harrold Building, North Terrace Adelaide South Australia 5000 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