{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:31:48Z","timestamp":1788870708248,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T00:00:00Z","timestamp":1401235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["DK37948"],"award-info":[{"award-number":["DK37948"]}]},{"name":"NIH","award":["DK 56341"],"award-info":[{"award-number":["DK 56341"]}]},{"name":"NIH","award":["UL1 RR024992"],"award-info":[{"award-number":["UL1 RR024992"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The effects of marked weight loss, induced by Roux\u2010en\u2010Y gastric bypass (RYGB) or sleeve gastrectomy (SG) surgeries, on insulin sensitivity, \u03b2\u2010cell function and the metabolic response to a mixed meal were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fourteen nondiabetic insulin\u2010resistant patients who were scheduled to undergo SG (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097) or RYGB (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097) procedures completed a hyperinsulinemic\u2010euglycemic clamp procedure and a mixed\u2010meal tolerance test before surgery and after losing \u223c20% of their initial body weight.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Insulin sensitivity (insulin\u2010stimulated glucose disposal during a clamp procedure), oral glucose tolerance (postprandial plasma glucose area under the curve), and \u03b2\u2010cell function (insulin secretion in relationship to insulin sensitivity) improved after weight loss, and were not different between surgical groups. The metabolic response to meal ingestion was similar after RYGB or SG, manifested by rapid delivery of ingested glucose into the systemic circulation and a large early postprandial increase in plasma glucose, insulin, and C\u2010peptide concentrations in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>When matched on weight loss, RYGB and SG surgeries result in similar improvements in the two major factors involved in regulating plasma glucose homeostasis, insulin sensitivity and \u03b2\u2010cell function in obese people without diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.20803","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T13:28:23Z","timestamp":1401283703000},"page":"2026-2031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Matched weight loss induced by sleeve gastrectomy or gastric bypass similarly improves metabolic function in obese subjects"],"prefix":"10.1002","volume":"22","author":[{"given":"David","family":"Bradley","sequence":"first","affiliation":[{"name":"Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine Washington University School of Medicine St. Louis Missouri USA"},{"name":"Division of Endocrinology Diabetes and Metabolism, The Ohio State University Medical Center Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faidon","family":"Magkos","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Christopher","family":"Eagon","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Esteban","family":"Varela","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Gastaldelli","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology of the National Research Council Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adewole L.","family":"Okunade","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce W.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Klein","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-012-0864-0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200225"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2010.326"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1596"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-009-0715-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-012-0622-3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64895"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904944106"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1959.tb44923.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.17.2.152"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100034"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2075"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.2007.S212"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1951"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181ae32e3"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-012-0622-3"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.20803","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.20803","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.20803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:36:37Z","timestamp":1696336597000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.20803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,28]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1002\/oby.20803"],"URL":"https:\/\/doi.org\/10.1002\/oby.20803","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,28]]},"assertion":[{"value":"2014-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}