{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:33:15Z","timestamp":1769275995067,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T00:00:00Z","timestamp":1402617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["320030_132960\/1"],"award-info":[{"award-number":["320030_132960\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The role of gastrointestinal (GI) hormones in the pathophysiology of obesity is unclear, although they are involved in the regulation of satiation and glucose metabolism. To (i) examine glucagon\u2010like peptide 1 (GLP\u20101), amylin, ghrelin, and glucagon responses to a meal in obese adolescents and to (ii) test which GI peptides are associated with insulin resistance are presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 16 obese (body mass index (BMI)\u2009\u2265\u200997th percentile for age and gender) and 14 control (BMI between 25th and 75th percentiles) adolescents were included. Subjects were instructed to eat a test meal (490 kcal). Plasma samples were collected for hormone and glucose analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Obese adolescents were insulin resistant as expressed by the Homeostasis Model Assessment (HOMA) index and had significantly increased fasting glucagon and amylin levels compared to the control group (<jats:italic>P<\/jats:italic>\u2009=\u20090.003 and 0.044, respectively).<\/jats:p><jats:p>In response to the meal, the increase in GLP\u20101 levels was reduced in obese adolescents (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In contrast, amylin secretion was significantly increased in the obese population compared to the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Obese adolescents have increased fasting glucagon and amylin levels and attenuated post\u2010prandial GLP\u20101 concentrations compared with the control group. These factors could contribute to the metabolic syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.20805","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T14:14:05Z","timestamp":1402668845000},"page":"2047-2052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of a test meal on meal responses of satiation hormones and their association to insulin resistance in obese adolescents"],"prefix":"10.1002","volume":"22","author":[{"given":"Svetlana","family":"Beglinger","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetology University Children's Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Christin","family":"Meyer\u2010Gerspach","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Biomedicine University Hospital Basel 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