{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:47:54Z","timestamp":1789757274240,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":390,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"EFSD New Horizons award","award":["2010"],"award-info":[{"award-number":["2010"]}]},{"name":"Pfizer Global Investigator Initiated Research Grant","award":["2010"],"award-info":[{"award-number":["2010"]}]},{"name":"Scientific Grant Agency of the Slovak Academy of Sciences grant","award":["2\/0198\/11"],"award-info":[{"award-number":["2\/0198\/11"]}]},{"name":"Scientific Grant Agency of the Slovak Academy of Sciences grant","award":["2\/0174\/12"],"award-info":[{"award-number":["2\/0174\/12"]}]},{"name":"Slovak Research and Development Agency Grant","award":["0122-06"],"award-info":[{"award-number":["0122-06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1002\/oby.20856","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T08:58:33Z","timestamp":1407401913000},"page":"322-328","source":"Crossref","is-referenced-by-count":11,"title":["Adipokine zinc-\u03b12-glycoprotein regulated by growth hormone and linked to insulin sensitivity"],"prefix":"10.1002","volume":"23","author":[{"given":"Miroslav","family":"Balaz","sequence":"first","affiliation":[{"name":"Institute of Experimental Endocrinology, Slovak Academy of Sciences; Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Ukropcova","sequence":"additional","affiliation":[{"name":"Institute of Experimental Endocrinology, Slovak Academy of Sciences; Bratislava Slovakia"},{"name":"Institute of Pathophysiology, Faculty of Medicine, Comenius University; Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timea","family":"Kurdiova","sequence":"additional","affiliation":[{"name":"Institute of Experimental Endocrinology, Slovak Academy of Sciences; Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Gajdosechova","sequence":"additional","affiliation":[{"name":"Institute of Experimental Endocrinology, Slovak Academy of Sciences; Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Vlcek","sequence":"additional","affiliation":[{"name":"Institute of Experimental Endocrinology, Slovak Academy of Sciences; Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Janakova","sequence":"additional","affiliation":[{"name":"Institute of Experimental Endocrinology, Slovak Academy of Sciences; Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"Fedeles","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department; University Hospital, Faculty of Medicine, Comenius University; Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikulas","family":"Pura","sequence":"additional","affiliation":[{"name":"Department of Endocrinology; National Institute of Endocrinology and Diabetology; Lubochna Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Gasperikova","sequence":"additional","affiliation":[{"name":"Institute of Experimental Endocrinology, Slovak Academy of Sciences; Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Sanford\/Burnham Medical Research Institute; Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruzena","family":"Tkacova","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine; Faculty of Medicine, P. J. Safarik University and L. Pasteur University Hospital; Kosice Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwar","family":"Klimes","sequence":"additional","affiliation":[{"name":"Institute of Experimental Endocrinology, Slovak Academy of Sciences; Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juraj","family":"Payer","sequence":"additional","affiliation":[{"name":"5th Department of Internal Medicine; University Hospital, Faculty of Medicine, Comenius University; Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Wolfrum","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Nutrition Biology, Institute of Food, Nutrition and Health, Swiss Federal Institute of Technology, ETH Zurich; Schwerzenbach Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"Ukropec","sequence":"additional","affiliation":[{"name":"Institute of Experimental Endocrinology, Slovak Academy of Sciences; Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,7]]},"reference":[{"key":"10.1002\/oby.20856-BIB0001|oby20856-cit-0001","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1043-2760(00)00301-5","article-title":"Adipose tissue as an endocrine organ","volume":"11","author":"Ahima","year":"2000","journal-title":"Trends Endocrinol Metab"},{"key":"10.1002\/oby.20856-BIB0002|oby20856-cit-0002","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"key":"10.1002\/oby.20856-BIB0003|oby20856-cit-0003","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nature05483","article-title":"Adipocytes as regulators of energy balance and glucose homeostasis","volume":"444","author":"Rosen","year":"2006","journal-title":"Nature"},{"key":"10.1002\/oby.20856-BIB0004|oby20856-cit-0004","doi-asserted-by":"crossref","first-page":"173498","DOI":"10.1155\/2010\/173498","article-title":"Metabolic phenotype and adipose tissue inflammation in patients with chronic obstructive pulmonary disease","volume":"2010","author":"Skyba","year":"2010","journal-title":"Mediators Inflamm"},{"key":"10.1002\/oby.20856-BIB0005|oby20856-cit-0005","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1210\/jc.2007-2188","article-title":"Adipokine protein expression pattern in growth hormone deficiency predisposes to the increased fat cell size and the whole body metabolic derangements","volume":"93","author":"Ukropec","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/oby.20856-BIB0006|oby20856-cit-0006","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/ijo.2010.193","article-title":"Studies on the anti-obesity activity of zinc-alpha2-glycoprotein in the rat","volume":"35","author":"Russell","year":"2011","journal-title":"Int J Obes (Lond)"},{"key":"10.1002\/oby.20856-BIB0007|oby20856-cit-0007","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/sj.bjc.6606083","article-title":"Enhanced ZAG production by subcutaneous adipose tissue is linked to weight loss in gastrointestinal cancer patients","volume":"104","author":"Mracek","year":"2011","journal-title":"Br J Cancer"},{"key":"10.1002\/oby.20856-BIB0008|oby20856-cit-0008","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/ijo.2010.105","article-title":"Zinc-alpha2-glycoprotein: an adipokine modulator of body fat mass?","volume":"34","author":"Bing","year":"2010","journal-title":"Int J Obes (Lond)"},{"key":"10.1002\/oby.20856-BIB0009|oby20856-cit-0009","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1002\/oby.20764","article-title":"Subcutaneous adipose tissue zinc-alpha2-glycoprotein is associated with adipose tissue and whole-body insulin sensitivity","volume":"22","author":"Balaz","year":"2014","journal-title":"Obesity (Silver Spring)"},{"key":"10.1002\/oby.20856-BIB0010|oby20856-cit-0010","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0021-9258(18)64243-7","article-title":"Preparation and properties of Zn-alpha 2-glycoprotein of normal human plasma","volume":"236","author":"Burgi","year":"1961","journal-title":"J Biol Chem"},{"key":"10.1002\/oby.20856-BIB0011|oby20856-cit-0011","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/0959-8049(93)90068-Q","article-title":"Zn-alpha 2-glycoprotein levels in breast cancer cytosols and correlation with clinical, histological and biochemical parameters","volume":"29A","author":"Diez-Itza","year":"1993","journal-title":"Eur J Cancer"},{"key":"10.1002\/oby.20856-BIB0012|oby20856-cit-0012","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1177\/39.9.1918940","article-title":"Immunohistochemical localization of Zn-alpha 2-glycoprotein in normal human tissues","volume":"39","author":"Tada","year":"1991","journal-title":"J Histochem Cytochem"},{"key":"10.1002\/oby.20856-BIB0013|oby20856-cit-0013","first-page":"2353","article-title":"Purification and characterization of a tumor lipid-mobilizing factor","volume":"58","author":"Todorov","year":"1998","journal-title":"Cancer Res"},{"key":"10.1002\/oby.20856-BIB0014|oby20856-cit-0014","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.febslet.2004.11.042","article-title":"Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SGBS) adipocytes","volume":"579","author":"Bao","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1002\/oby.20856-BIB0015|oby20856-cit-0015","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1365-2265.2009.03658.x","article-title":"The adipokine zinc-alpha2-glycoprotein (ZAG) is downregulated with fat mass expansion in obesity","volume":"72","author":"Mracek","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1002\/oby.20856-BIB0016|oby20856-cit-0016","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mce.2010.05.020","article-title":"Macrophage-secreted factors inhibit ZAG expression and secretion by human adipocytes","volume":"325","author":"Gao","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1002\/oby.20856-BIB0017|oby20856-cit-0017","first-page":"2359","article-title":"Biological evaluation of a lipid-mobilizing factor isolated from the urine of cancer patients","volume":"58","author":"Hirai","year":"1998","journal-title":"Cancer Res"},{"key":"10.1002\/oby.20856-BIB0018|oby20856-cit-0018","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.febslet.2006.12.047","article-title":"Lipolysis is altered in MHC class I zinc-alpha(2)-glycoprotein deficient mice","volume":"581","author":"Rolli","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1002\/oby.20856-BIB0019|oby20856-cit-0019","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1365-2796.2011.02441.x","article-title":"Adipose zinc-alpha2-glycoprotein is a catabolic marker in cancer and noncancerous states","volume":"271","author":"Ryden","year":"2012","journal-title":"J Intern Med"},{"key":"10.1002\/oby.20856-BIB0020|oby20856-cit-0020","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/ijo.2009.141","article-title":"Zinc-alpha2-glycoprotein is involved in regulation of body weight through inhibition of lipogenic enzymes in adipose tissue","volume":"33","author":"Gong","year":"2009","journal-title":"Int J Obes (Lond)"},{"key":"10.1002\/oby.20856-BIB0021|oby20856-cit-0021","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1210\/jcem.87.5.8482","article-title":"Effects of seven years of GH-replacement therapy on insulin sensitivity in GH-deficient adults","volume":"87","author":"Svensson","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/oby.20856-BIB0022|oby20856-cit-0022","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1210\/er.2008-0027","article-title":"Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects","volume":"30","author":"Moller","year":"2009","journal-title":"Endocr Rev"},{"key":"10.1002\/oby.20856-BIB0023|oby20856-cit-0023","first-page":"727","article-title":"Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure","volume":"82","author":"Johannsson","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/oby.20856-BIB0024|oby20856-cit-0024","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1210\/jc.2008-1357","article-title":"Effects of recombinant human growth hormone therapy in obesity in adults: a meta analysis","volume":"94","author":"Mekala","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/oby.20856-BIB0025|oby20856-cit-0025","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ecl.2012.04.011","article-title":"The insulin-like growth factors in adipogenesis and obesity","volume":"41","author":"Garten","year":"2012","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1002\/oby.20856-BIB0026|oby20856-cit-0026","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1007\/s00125-010-1738-4","article-title":"Improved insulin sensitivity, preserved beta cell function and improved whole-body glucose metabolism after low-dose growth hormone replacement therapy in adults with severe growth hormone deficiency: a pilot study","volume":"53","author":"Arafat","year":"2010","journal-title":"Diabetologia"},{"key":"10.1002\/oby.20856-BIB0027|oby20856-cit-0027","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1210\/jc.2007-0786","article-title":"Effect of growth hormone on body composition and visceral adiposity in middle-aged men with visceral obesity","volume":"92","author":"Pasarica","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/oby.20856-BIB0028|oby20856-cit-0028","doi-asserted-by":"crossref","first-page":"e82086","DOI":"10.1371\/journal.pone.0082086","article-title":"Ursodeoxycholic Acid but not tauroursodeoxycholic acid inhibits proliferation and differentiation of human subcutaneous adipocytes","volume":"8","author":"Malisova","year":"2013","journal-title":"PLoS One"},{"key":"10.1002\/oby.20856-BIB0029|oby20856-cit-0029","first-page":"E86","article-title":"Effects of a growth hormone pulse on total and forearm substrate fluxes in humans","volume":"258","author":"Moller","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1002\/oby.20856-BIB0030|oby20856-cit-0030","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1172\/JCI105126","article-title":"Effect of human growth hormone on muscle and adipose tissue metabolism in the forearm of man","volume":"44","author":"Rabinowitz","year":"1965","journal-title":"J Clin Invest"},{"key":"10.1002\/oby.20856-BIB0031|oby20856-cit-0031","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1365-2265.2007.02763.x","article-title":"Modulation of glucocorticoid metabolism by the growth hormone-IGF-1 axis","volume":"66","author":"Agha","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1002\/oby.20856-BIB0032|oby20856-cit-0032","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1210\/jc.2005-1694","article-title":"Growth hormone (GH) substitution in GH-deficient patients inhibits 11beta-hydroxysteroid dehydrogenase type 1 messenger ribonucleic acid expression in adipose tissue","volume":"91","author":"Paulsen","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/oby.20856-BIB0033|oby20856-cit-0033","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ijo.2010.150","article-title":"Studies on the antiobesity effect of zinc-alpha2-glycoprotein in the ob\/ob mouse","volume":"35","author":"Russell","year":"2011","journal-title":"Int J Obes (Lond)"},{"key":"10.1002\/oby.20856-BIB0034|oby20856-cit-0034","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1210\/jc.2009-0758","article-title":"Lower zinc-alpha2-glycoprotein production by adipose tissue and liver in obese patients unrelated to insulin resistance","volume":"94","author":"Selva","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/oby.20856-BIB0035|oby20856-cit-0035","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF03168235","article-title":"ZAG, a lipid mobilizing adipokine, is downregulated in human obesity","volume":"64","author":"Marrades","year":"2008","journal-title":"J Physiol Biochem"},{"key":"10.1002\/oby.20856-BIB0036|oby20856-cit-0036","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.atherosclerosis.2010.08.046","article-title":"Phosphorylation of sterol regulatory element-binding protein (SREBP)\u22121a links growth hormone action to lipid metabolism in hepatocytes","volume":"213","author":"Kotzka","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1002\/oby.20856-BIB0037|oby20856-cit-0037","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.metabol.2011.05.011","article-title":"Serum adipokine zinc alpha2-glycoprotein and lipolysis in cachectic and noncachectic heart failure patients: relationship with neurohormonal and inflammatory biomarkers","volume":"61","author":"Tedeschi","year":"2012","journal-title":"Metabolism"},{"key":"10.1002\/oby.20856-BIB0038|oby20856-cit-0038","doi-asserted-by":"crossref","first-page":"e33264","DOI":"10.1371\/journal.pone.0033264","article-title":"Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients","volume":"7","author":"Garrido-Sanchez","year":"2012","journal-title":"PLoS One"},{"key":"10.1002\/oby.20856-BIB0039|oby20856-cit-0039","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/oby.2009.335","article-title":"Release of 12 adipokines by adipose tissue, nonfat cells, and fat cells from obese women","volume":"18","author":"Fain","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"10.1002\/oby.20856-BIB0040|oby20856-cit-0040","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.bbalip.2011.12.003","article-title":"Role of beta-adrenergic receptors in the anti-obesity and anti-diabetic effects of zinc-alpha2-glycoprotien (ZAG)","volume":"1821","author":"Russell","year":"2012","journal-title":"Biochim Biophys Acta"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.20856","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/oby.20856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:50:51Z","timestamp":1717203051000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.20856"}},"subtitle":["ZAG in Obesity and GH Deficiency"],"short-title":[],"issued":{"date-parts":[[2014,8,7]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"URL":"https:\/\/doi.org\/10.1002\/oby.20856","relation":{},"ISSN":["1930-7381"],"issn-type":[{"value":"1930-7381","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8,7]]}}}