{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:28:02Z","timestamp":1790116082533,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T00:00:00Z","timestamp":1412726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK083297"],"award-info":[{"award-number":["R01DK083297"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the impact of a weight loss intervention upon follicle stimulating hormone (FSH) levels in postmenopause.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were postmenopausal, overweight, glucose\u2010intolerant women not using exogenous estrogen (<jats:italic>n<\/jats:italic>\u2009=\u2009382) in the Diabetes Prevention Program. Women were randomized to intensive lifestyle change (ILS) with the goals of weight reduction of at least 7% of initial weight and 150 min per week of moderate\u2010intensity exercise, metformin 850 mg twice a day, or placebo administered twice a day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Randomization to ILS led to small increases in FSH between baseline and 1\u2010year follow\u2010up vs. placebo (2.3 IU\/l vs. \u22120.81 IU\/l, <jats:italic>P<\/jats:italic> &lt; 0.01). Increases in FSH were correlated with decreases in weight (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.165, <jats:italic>P<\/jats:italic> &lt; 0.01) and estradiol (E2) (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.464, <jats:italic>P<\/jats:italic> &lt; 0.0001) after adjustment for age, race\/ethnicity, and randomization arm. Changes in FSH were still significantly associated with changes in weight even after adjustment for E2 levels. Metformin users had reductions in weight but non\u2010significant changes in FSH and E2 levels vs. placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Weight loss leads to small increases in FSH among overweight, postmenopausal women, potentially through pathways mediated by endogenous estrogen as well as other pathways.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.20917","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T07:33:49Z","timestamp":1412753629000},"page":"228-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Weight loss decreases follicle stimulating hormone in overweight postmenopausal women"],"prefix":"10.1002","volume":"23","author":[{"given":"Catherine","family":"Kim","sequence":"first","affiliation":[{"name":"Departments of Medicine and Obstetrics &amp; Gynecology University of Michigan  Ann Arbor Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Randolph","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Michigan  Ann Arbor Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherita H.","family":"Golden","sequence":"additional","affiliation":[{"name":"Department of Medicine Johns Hopkins University  Baltimore Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernand","family":"Labrie","sequence":"additional","affiliation":[{"name":"Laval University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengchun","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Statistics Purdue University  West Lafayette Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Nan","sequence":"additional","affiliation":[{"name":"Department of Statistics Purdue University  West Lafayette Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Barrett\u2010Connor","sequence":"additional","affiliation":[{"name":"Dept. of Preventive Medicine University of California San Diego San Diego, California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181cec85d"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1422"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg022"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0643"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.232"},{"key":"e_1_2_6_7_1","volume-title":"BMC Women's Health","author":"Waaseth 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