{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:46:52Z","timestamp":1773420412088,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T00:00:00Z","timestamp":1422921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006495","name":"Dr. Robert C. and Veronica Atkins Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006495","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SC CTSI (NIH\/NCRR\/NCATS)","award":["TL1TR000132"],"award-info":[{"award-number":["TL1TR000132"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Salsalate treatment has well\u2010known effects on improving glycemia, and the objective of this study was to examine whether the mechanism of this effect was related to changes in adipose tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized double\u2010blind and placebo\u2010controlled trial in obese Hispanics (18\u201035 years) was conducted. The intervention consisted of 4 g day<jats:sup>\u22121<\/jats:sup> of salsalate (<jats:italic>n<\/jats:italic> = 11) versus placebo (<jats:italic>n<\/jats:italic> = 13) for 4 weeks. Outcome measures included glycemia, adiposity, ectopic fat, and adipose tissue gene expression and inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In those receiving salsalate, plasma fasting glucose decreased by 3.4% (<jats:italic>P<\/jats:italic> &lt; 0.01), free fatty acids decreased by 42.5% (<jats:italic>P<\/jats:italic> = 0.06), and adiponectin increased by 27.7% (<jats:italic>P<\/jats:italic> &lt; 0.01). Salsalate increased insulin AUC by 38% (<jats:italic>P<\/jats:italic> = 0.01) and HOMA\u2010B by 47.2% (<jats:italic>P<\/jats:italic> &lt; 0.01) while estimates of insulin sensitivity\/resistance were unaffected. These metabolic improvements occurred without changes in total, abdominal, visceral, or liver fat. Plasma markers of inflammation\/immune activation were unchanged following salsalate. Salsalate had no effects on adipose tissue including adipocyte size, presence of crown\u2010like structures, or gene expression of adipokines, immune cell markers, or cytokines downstream of NF\u2010\u03baB with the exception of downregulation of IL\u20101\u03b2 (<jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings suggest that metabolic improvements in response to salsalate occurred without alterations in adiposity, ectopic fat, or adipose tissue gene expression and inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.20991","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T07:21:26Z","timestamp":1422948086000},"page":"543-551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Salsalate treatment improves glycemia without altering adipose tissue in nondiabetic obese hispanics"],"prefix":"10.1002","volume":"23","author":[{"given":"Tanya L.","family":"Alderete","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine University of Southern California Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred R","family":"Sattler","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Southern California Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce M.","family":"Richey","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Keck School of Medicine University of Southern California Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hooman","family":"Allayee","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Institute for Genetic Medicine, Keck School of Medicine University of 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