{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:38:46Z","timestamp":1792103926820,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T00:00:00Z","timestamp":1425859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CARDIA","award":["HHSN268201300025C"],"award-info":[{"award-number":["HHSN268201300025C"]}]},{"name":"CARDIA","award":["HHSN268201300026C"],"award-info":[{"award-number":["HHSN268201300026C"]}]},{"name":"CARDIA","award":["HHSN268201300027C"],"award-info":[{"award-number":["HHSN268201300027C"]}]},{"name":"CARDIA","award":["HHSN268201300028C"],"award-info":[{"award-number":["HHSN268201300028C"]}]},{"name":"CARDIA","award":["HHSN268201300029C"],"award-info":[{"award-number":["HHSN268201300029C"]}]},{"name":"CARDIA","award":["HHSN268200900041C"],"award-info":[{"award-number":["HHSN268200900041C"]}]},{"name":"Intramural Research Program of the NIA, and an intra-agency agreement between NIA and NHLBI","award":["AG0005"],"award-info":[{"award-number":["AG0005"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the influence of the total cumulative exposure to excess overall and abdominal adiposity on the incidence of cardiovascular disease (CVD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective study of 4,061 white and black adults without CVD at baseline in 1985\u20101986 (age 18\u201030 years) from the multicenter, community\u2010based CARDIA study. Time\u2010varying excess body mass index (BMI)\u2010 and waist circumference (WC)\u2010years were calculated as products of the degree and duration of excess overall (BMI\u2009\u2265\u200925 kg\/m<jats:sup>2<\/jats:sup>) and abdominal adiposity [WC &gt;94 cm (men) and &gt;80 cm (women)], respectively, collected at up to eight examinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median of 24.8 years, there were 125 incident CVD, 62 coronary heart disease (CHD), and 33 heart failure (HF) events. Adjusted hazard ratios for CVD, CHD, and HF for each additional 50 excess BMI\u2010years were 1.20 (1.08, 1.34), 1.25 (1.07, 1.46), and 1.45 (1.23, 1.72), respectively. For each 50 excess WC\u2010years, these hazard ratios were 1.10 (1.04, 1.18), 1.13 (1.03, 1.24), and 1.22 (1.11, 1.34), respectively. Akaike information criterion values were lowest in models containing time\u2010varying excess BMI\u2010 or WC\u2010years compared to those including time\u2010varying BMI or WC only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Excess BMI\u2010 and WC\u2010years are predictors of the risk of CVD and may provide a better indicator of the cumulative exposure to excess adiposity than BMI or WC only.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21023","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T05:13:48Z","timestamp":1425964428000},"page":"879-885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Excess body mass index\u2010 and waist circumference\u2010years and incident cardiovascular disease: The CARDIA study"],"prefix":"10.1002","volume":"23","author":[{"given":"Jared P.","family":"Reis","sequence":"first","affiliation":[{"name":"Division of 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Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Loria","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Sciences National Heart, Lung, and Blood Institute Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany M.","family":"Powell\u2010Wiley","sequence":"additional","affiliation":[{"name":"Cardiovascular and Pulmonary Branch National Heart, Lung, and Blood Institute and Applied Research Program, Division of Cancer Control &amp; Population Studies, National Cancer Institute Bethesda Maryland USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal S.","family":"Rana","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California Oakland California 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