{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:32:46Z","timestamp":1791516766538,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,7]],"date-time":"2015-03-07T00:00:00Z","timestamp":1425686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30-DK036836"],"award-info":[{"award-number":["P30-DK036836"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"American Society of Metabolic and Bariatric Surgery"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81170779"],"award-info":[{"award-number":["81170779"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Hyperinsulinemic hypoglycemia with neuroglycopenia is a rare complication following Roux\u2010en\u2010Y gastric bypass (RYGB) surgery for weight management. Insulin secretion and action in response to oral and intravenous stimuli in persons with and without neuroglycopenia following RYGB are evaluated in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional cohort studies were performed at a single academic institution to assess insulin secretion and action during oral mixed meal tolerance test and intravenous glucose tolerance test (IVGTT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Insulin secretion was increased more following oral mixed meal than intravenous glucose in individuals with neuroglycopenia compared to the asymptomatic group. Reduced insulin clearance did not contribute to higher insulinemia. Glucose effectiveness at zero insulin, estimated during the IVGTT, was also higher in those with neuroglycopenia. Insulin sensitivity did not differ between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased beta\u2010cell response to oral stimuli and insulin\u2010independent glucose disposal may both contribute to severe hypoglycemia after RYGB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21043","type":"journal-article","created":{"date-parts":[[2015,3,7]],"date-time":"2015-03-07T10:53:46Z","timestamp":1425725626000},"page":"798-807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Insulin response to oral stimuli and glucose effectiveness increased in neuroglycopenia following gastric bypass"],"prefix":"10.1002","volume":"23","author":[{"given":"Mary Elizabeth","family":"Patti","sequence":"first","affiliation":[{"name":"Research Division Joslin Diabetes Center, and Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Research Division Joslin Diabetes Center, and Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Endocrinology Shengjing Hospital of China Medical University Shenyang Liaoning Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison B.","family":"Goldfine","sequence":"additional","affiliation":[{"name":"Research Division Joslin Diabetes Center, and Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1933-x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043690"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1798-5"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-014-1260-8"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2008.05.005"},{"key":"e_1_2_5_7_1","first-page":"A27","article-title":"Continuous Glucose Measuring Reveals Frequent","volume":"63","author":"Abrahamsson N","year":"2014","journal-title":"and Mainly Unnoticed Hypoglycemias After Bariatric Surgery 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