{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:31:58Z","timestamp":1792114318616,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T00:00:00Z","timestamp":1429228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Seattle Children's Hospital from the Nordstrom and Gittinger families"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Excessive weight gain frequently occurs in patients with hypothalamic tumors and lesions leading to hypothalamic obesity (HO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Digital brain magnetic resonance imaging (MRI) and clinical outcomes were studied retrospectively in a single center, including 45 children with postoperative lesions in the sellar region (41 craniopharyngiomas, 4 with Rathke's cleft cysts), \u223c5 years post\u2010surgery, mean age 13.9 years. Four standard sections covering hypothalamic areas critical to energy homeostasis were used to assess lesions and calculate a hypothalamic lesion score (HLS); the association with HO was examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to subjects who did not develop HO (<jats:italic>n<\/jats:italic> = 23), subjects with HO (<jats:italic>n<\/jats:italic> = 22) showed more frequently lesions affecting the third ventricular floor, mammillary bodies, and anterior, medial (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and most importantly posterior hypothalamus (<jats:italic>P<\/jats:italic> &lt; 0.01). The HLS correlated significantly with BMI <jats:italic>z<\/jats:italic>\u2010score changes 12 and 30 months post\u2010surgery, even after adjusting for potential confounders of gender, age at surgery, surgery date, surgery BMI <jats:italic>z<\/jats:italic>\u2010score, hydrocephalus, and residual hypothalamic tumor (<jats:italic>r<\/jats:italic> = 0.34, <jats:italic>P<\/jats:italic> = 0.03; <jats:italic>r<\/jats:italic> = 0.40, <jats:italic>P<\/jats:italic> = 0.02, respectively). Diabetes insipidus was found to be an endocrine marker for HO risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The extent of damage following surgery in the sellar region can be assessed by MRI using a novel scoring system for early HO risk assessment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21067","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T09:39:41Z","timestamp":1429263581000},"page":"1226-1233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Semiquantitative analysis of hypothalamic damage on <scp>MRI<\/scp> predicts risk for hypothalamic obesity"],"prefix":"10.1002","volume":"23","author":[{"given":"Christian L.","family":"Roth","sequence":"first","affiliation":[{"name":"Center for Integrative Brain Research, Seattle Children's Hospital &amp; Research Institute Seattle Washington USA"},{"name":"Pediatric Endocrinology Seattle Children's Hospital &amp; Research Institute Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedieh","family":"Eslamy","sequence":"additional","affiliation":[{"name":"Neuroradiology Seattle Children's Hospital &amp; Research Institute Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Werny","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Seattle Children's Hospital &amp; Research Institute Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton","family":"Elfers","sequence":"additional","affiliation":[{"name":"Center for Integrative Brain Research, Seattle Children's Hospital &amp; Research Institute Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele L.","family":"Shaffer","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Research, Seattle Children's Hospital &amp; Research Institute Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Pihoker","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Seattle Children's Hospital &amp; Research Institute Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Ojemann","sequence":"additional","affiliation":[{"name":"Neurosurgery, Seattle Children's Hospital &amp; Research Institute Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Dobyns","sequence":"additional","affiliation":[{"name":"Center for Integrative Brain Research, Seattle Children's Hospital &amp; Research Institute Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031751"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not151"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2393050823"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2069"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1994.80.6.1018"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.125"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3282495a22"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fendo.2011.00081","article-title":"Long term sequelae of pediatric craniopharyngioma \u2010 literature review and 20 years of experience","volume":"2","author":"Cohen M","year":"2011","journal-title":"Front Endocrinol (Lausanne)"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/417949"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2012.01004.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2011.00060"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-030003"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0826"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0158"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3928"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.7.2734"},{"key":"e_1_2_5_18_1","volume-title":"Atlas of the human brain","author":"Mai JK","year":"1997"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.02.056"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.024"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.07.013"},{"key":"e_1_2_5_22_1","first-page":"1","article-title":"Construction of LMS parameters for the Centers for Disease Control and Prevention 2000 growth charts","author":"Flegal KM","year":"2013","journal-title":"Natl Health Stat Report"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1988.tb10705.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-42722"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.1.FOCUS09303"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-16855"},{"key":"e_1_2_5_27_1","first-page":"3","article-title":"Pediatric craniopharyngiomas: classification and treatment according to the degree of hypothalamic involvement","volume":"106","author":"Puget S","year":"2007","journal-title":"J Neurosurg"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.80"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2010.00727.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.06.035"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.10.019"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05026"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095004"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0184"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03094-8"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2014.05.004"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021797"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0993"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e3180332cd6"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182083b67"},{"key":"e_1_2_5_41_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fendo.2012.00023","article-title":"Bariatric surgery in hypothalamic obesity","volume":"3","author":"Bingham NC","year":"2012","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.21067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.21067","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.21067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.21067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.21067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:56:24Z","timestamp":1696366584000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.21067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,17]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1002\/oby.21067"],"URL":"https:\/\/doi.org\/10.1002\/oby.21067","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,17]]},"assertion":[{"value":"2014-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}