{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:29:03Z","timestamp":1791210543600,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","award":["CIHR - #131594"],"award-info":[{"award-number":["CIHR - #131594"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine whether changes in modifiable risk factors [physical activity, cardiorespiratory fitness (CRF), body weight, and diet composition] are associated with the transition to metabolically healthy overweight\/obese (MHOW) versus metabolically abnormal overweight\/obese.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Analysis included 1,358 adults [aged 25.0 (3.5) years] from the CARDIA study who were healthy at baseline and had overweight\/obesity at follow\u2010up. Participants with zero or one of the following six risk factors were classified as MHOW: elevated triglycerides, LDL, blood pressure, fasting glucose, and HOMA\u2010insulin resistance and low HDL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over the 20\u2010year follow\u2010up, the sample gained weight (BMI 24.5 to 31.1 kg\/m<jats:sup>2<\/jats:sup>), and the prevalence of MHOW was 47% at follow\u2010up. After adjusting for changes in CRF, diet, and weight change, physical activity and macronutrient intake were not independently associated with MHOW (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05), while changes in CRF [fit\u2013unfit: RR (95%)\u2009=\u20090.58, 0.52\u20100.66; unfit\u2013unfit: RR\u2009=\u20090.67, 0.58\u20100.76, versus fit\u2013fit] and weight [gain: RR (95%)\u2009=\u20090.54, 0.43\u20100.67; cycle: RR\u2009=\u20090.74, 0.57\u20100.94, versus stable] were independently associated with MHOW.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Focusing on high CRF and strategies to limit weight gain may be important for individuals with overweight and obesity in early to mid\u2010adulthood to maintain a metabolically healthy profile.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21087","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T08:16:34Z","timestamp":1432628194000},"page":"1320-1325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Lifestyle and weight predictors of a healthy overweight profile over a 20\u2010year follow\u2010up"],"prefix":"10.1002","volume":"23","author":[{"given":"Michael D.T.","family":"Fung","sequence":"first","affiliation":[{"name":"School of Kinesiology, York University, Sherman Health Science Research Centre Toronto Ontario Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karissa L.","family":"Canning","sequence":"additional","affiliation":[{"name":"School of Kinesiology, York University, Sherman Health Science Research Centre Toronto Ontario Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mirdamadi","sequence":"additional","affiliation":[{"name":"School of Kinesiology, York University, Sherman Health Science Research Centre Toronto Ontario Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris I.","family":"Ardern","sequence":"additional","affiliation":[{"name":"School of Kinesiology, York University, Sherman Health Science Research Centre Toronto Ontario Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Kuk","sequence":"additional","affiliation":[{"name":"School of Kinesiology, York University, Sherman Health Science Research Centre Toronto Ontario Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp068177"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0372"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.3.1020"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.15.1617"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076188"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60460-8"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-7954-10-22"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200106001-00007"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803739"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1971"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90080-7"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.23.3092"},{"key":"e_1_2_5_14_1","first-page":"5","article-title":"Cardiovascular risk factors in young adults","volume":"1","author":"Cutter GR","year":"1991","journal-title":"CARDIA Baseline Monograph"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115835"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(03)00895-1"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","unstructured":"LeeI RexrodeKM CookNR MansonJE BuringJE PageP. 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