{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:42:28Z","timestamp":1790707348342,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["K01HL125503"],"award-info":[{"award-number":["K01HL125503"]}]},{"name":"NIH","award":["RR013223"],"award-info":[{"award-number":["RR013223"]}]},{"name":"NIH","award":["HL062552"],"award-info":[{"award-number":["HL062552"]}]},{"name":"University of Missouri Mizzou Advantage","award":["VA-CDA2-1299"],"award-info":[{"award-number":["VA-CDA2-1299"]}]},{"DOI":"10.13039\/100008796","name":"Allen Foundation Inc","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008796","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Dr. Michael Sturek and the Comparative Medicine Center of IUSM and Purdue University for the female Ossabaw swine used in this study"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The Ossabaw pig is emerging as an attractive model of human cardiometabolic disease because of its size and susceptibility to atherosclerosis, among other characteristics. The relationship between adipose tissue inflammation and metabolic dysfunction in this model was investigated here.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Young female Ossabaw pigs were fed a Western\u2010style high\u2010fat diet (HFD) (<jats:italic>n<\/jats:italic>\u2009=\u20094) or control low\u2010fat diet (LFD) (<jats:italic>n<\/jats:italic>\u2009=\u20094) for a period of 9 months and compared for cardiometabolic outcomes and adipose tissue inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The HFD\u2010fed \u201cOBESE\u201d pigs were 2.5 times heavier (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) than LFD\u2010fed \u201cLEAN\u201d pigs and developed severe obesity. HFD feeding caused pronounced dyslipidemia, hypertension, and insulin resistance (systemic and adipose), as well as induction of inflammatory genes, impairments in vasomotor reactivity to insulin, and atherosclerosis in the coronary arteries. Remarkably, visceral, subcutaneous, and perivascular adipose tissue inflammation (via FACS analysis and RT\u2010PCR) was not increased in OBESE pigs, nor were circulating inflammatory cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings reveal a disconnect between adipose tissue inflammation and cardiometabolic dysfunction induced by Western diet feeding in the Ossabaw pig model.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21252","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T13:38:44Z","timestamp":1446471524000},"page":"2421-2429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs"],"prefix":"10.1002","volume":"23","author":[{"given":"Victoria J.","family":"Vieira\u2010Potter","sequence":"first","affiliation":[{"name":"Department of Nutrition and Exercise Physiology University of Missouri Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sewon","family":"Lee","sequence":"additional","affiliation":[{"name":"Dalton Cardiovascular Research Center, University of Missouri Columbia Missouri USA"},{"name":"Division of Sport Science and Sport Science Institute Incheon National University Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Bayless","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology and Physiology University of Missouri Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Scroggins","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Exercise Physiology University of Missouri Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Welly","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Exercise Physiology University of Missouri Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Fleming","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Exercise Physiology University of Missouri Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas N.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Exercise Physiology University of Missouri Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace M.","family":"Meers","sequence":"additional","affiliation":[{"name":"Research Service Harry S. 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