{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:28:14Z","timestamp":1790130494221,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Center of Medical Systems Biology"},{"DOI":"10.13039\/501100005039","name":"Leiden University Medical Center","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005039","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Rembrandt Institute of Cardiovascular Science"},{"name":"PCNR is Established Investigator of the Netherlands Heart Foundation","award":["2009T038"],"award-info":[{"award-number":["2009T038"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Pathogenic immunoglobulins are produced during the development of obesity and contribute to the development of insulin resistance (IR). However, the mechanisms by which these antibodies affect IR are largely unknown. This study investigated whether Fc\u2010receptors contribute to the development of diet\u2010induced obesity and IR by studying FcR\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup> mice that lack the \u03b3\u2010subunit necessary for signaling and cell surface expression of Fc\u03b3R and Fc\u03b5RI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>FcR\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup> and wild\u2010type (WT) mice were fed a high\u2010fat diet (HFD) to induce obesity. At 4 and 11 weeks, body weight and insulin sensitivity were measured, and adipose tissue (AT) inflammation was determined. Furthermore, intestinal triglyceride (TG) uptake and plasma TG clearance were determined, and gut microbiota composition was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FcR\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup> mice gained less weight after 11 weeks of HFD. They had reduced adiposity, adipose tissue inflammation, and IR. Interestingly, FcR\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup> mice had higher lean mass compared to WT mice, which was associated with increased energy expenditure. Intestinal TG absorption was increased whereas plasma TG clearance was not affected in FcR\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup> mice. Gut microbial composition differed significantly and might therefore have added to the observed phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FcR\u03b3\u2010chain deficiency reduces the development of diet\u2010induced obesity, as well as associated AT inflammation and IR at 11 weeks of HFD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21309","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T13:41:22Z","timestamp":1446471682000},"page":"2435-2444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<scp>F<\/scp>c<scp>R<\/scp>\u03b3\u2010chain deficiency reduces the development of diet\u2010induced obesity"],"prefix":"10.1002","volume":"23","author":[{"given":"Lianne","family":"van Beek","sequence":"first","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center Leiden the Netherlands"},{"name":"Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene O.C.M.","family":"Vroegrijk","sequence":"additional","affiliation":[{"name":"Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden the Netherlands"},{"name":"Department of Medicine Division Endocrinology, Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Katiraei","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center Leiden the Netherlands"},{"name":"Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattijs M.","family":"Heemskerk","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center Leiden the Netherlands"},{"name":"Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea D.","family":"van Dam","sequence":"additional","affiliation":[{"name":"Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden the Netherlands"},{"name":"Department of Medicine Division Endocrinology, Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Kooijman","sequence":"additional","affiliation":[{"name":"Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden the Netherlands"},{"name":"Department of Medicine Division Endocrinology, Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C.N.","family":"Rensen","sequence":"additional","affiliation":[{"name":"Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden the Netherlands"},{"name":"Department of Medicine Division Endocrinology, Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits","family":"Koning","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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