{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:28:03Z","timestamp":1790958483302,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,6]],"date-time":"2015-12-06T00:00:00Z","timestamp":1449360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To test for differential weight loss response to low\u2010fat (LF) vs. low\u2010carbohydrate (LC) diets by insulin resistance status with emphasis on overall quality of both diets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010one adults, BMI 28\u201040 kg\/m<jats:sup>2<\/jats:sup>, were randomized in a 2 \u00d7 2 design to LF or LC by insulin resistance status in this pilot study. Primary outcome was 6\u2010month weight change. Participants were characterized as more insulin resistant (IR) or more insulin sensitive (IS) by median split of baseline insulin\u2010area\u2010under\u2010the\u2010curve from an oral glucose tolerance test. Intervention consisted of 14 one\u2010hour class\u2010based educational sessions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline % carbohydrate:% fat:% protein was 44:38:18. At 6 months, the LF group reported 57:21:22 and the LC group reported 22:53:25 (IR and IS combined). Six\u2010month weight loss (kg) was 7.4\u2009\u00b1\u20096.0 (LF\u2010IR), 10.4\u2009\u00b1\u20097.8 (LF\u2010IS), 9.6\u2009\u00b1\u20096.6 (LC\u2010IR), and 8.6\u2009\u00b1\u20095.6 (LC\u2010IS). No significant main effects were detected for weight loss by diet group or IR status; there was no significant diet \u00d7 IR interaction. Significant differences in several secondary outcomes were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Substantial weight loss was achieved overall, but a significant diet \u00d7 IR status interaction was not observed. Opportunity to detect differential response may have been limited by the focus on high diet quality for both diet groups and sample size.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21331","type":"journal-article","created":{"date-parts":[[2015,12,6]],"date-time":"2015-12-06T07:52:53Z","timestamp":1449388373000},"page":"79-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Weight loss on low\u2010fat vs. low\u2010carbohydrate diets by insulin resistance status among overweight adults and adults with obesity: A randomized pilot trial"],"prefix":"10.1002","volume":"24","author":[{"given":"Christopher D.","family":"Gardner","sequence":"first","affiliation":[{"name":"Stanford Prevention Research Center, Department of Medicine Stanford University Medical School Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa C.","family":"Offringa","sequence":"additional","affiliation":[{"name":"Stanford Prevention Research Center, Department of Medicine Stanford University Medical School Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Hartle","sequence":"additional","affiliation":[{"name":"Stanford Prevention Research Center, Department of Medicine Stanford University Medical School Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"Kapphahn","sequence":"additional","affiliation":[{"name":"Quantitative Sciences Unit, Department of Medicine Stanford University Medical School Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rise","family":"Cherin","sequence":"additional","affiliation":[{"name":"Stanford Prevention Research Center, Department of Medicine Stanford University Medical School Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,6]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Centers for Disease Control and Prevention. 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