{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:40:46Z","timestamp":1777470046024,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,6]],"date-time":"2015-12-06T00:00:00Z","timestamp":1449360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Siblings born before (BMS) and after (AMS) maternal biliopancreatic diversion (BPD) show differences in the methylome. The objective was to use a sibling\u2010pair design to examine the effects from interpregnancy weight loss as a consequence of maternal bariatric surgery, other than BPD, on the methylome comparing BMS and AMS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women with at least one child born before and one after bariatric surgery were identified in Swedish national registers. Whole blood samples from BMS (<jats:italic>N<\/jats:italic>\u2009=\u200931) and AMS (<jats:italic>N<\/jats:italic>\u2009=\u200931) siblings were collected for epigenetic methylation analysis while maternal information was collected from antenatal medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total 3,074 genes, with corresponding 23,449 CpG methylation sites, were differently methylated and associated with an overrepresentation of differently methylated CpG sites in genes involved with insulin receptor signaling, type 2 diabetes signaling, and leptin signaling in obesity, while the most significant differently methylated genes were <jats:italic>HLA\u2010DQA1, HLA\u2010DQB1,<\/jats:italic> and <jats:italic>TSPAN18,<\/jats:italic> when comparing BMS and AMS siblings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that maternal bariatric surgery, with subsequent weight loss between pregnancies, is associated with alterations in the methylome of genes involved in insulin receptor signaling, type 2 diabetes signaling, and leptin signaling in obesity in a comparison of BMS and AMS siblings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21340","type":"journal-article","created":{"date-parts":[[2015,12,6]],"date-time":"2015-12-06T12:47:24Z","timestamp":1449406044000},"page":"250-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Differential methylation in inflammation and type 2 diabetes genes in siblings born before and after maternal bariatric surgery"],"prefix":"10.1002","volume":"24","author":[{"given":"Daniel","family":"Berglind","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of 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