{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:07:58Z","timestamp":1784783278398,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T00:00:00Z","timestamp":1452038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the associations of infant subcutaneous fat with cardiovascular risk factors at school\u2010age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a population\u2010based prospective cohort study among 808 children, total subcutaneous fat (sum of biceps, triceps, suprailiacal, and subscapular skinfold thicknesses) and central\u2010to\u2010total subcutaneous fat ratio (sum of suprailiacal and subscapular skinfold thicknesses\/total subcutaneous fat) at 1.5 and 24 months were estimated. At 6 years, body mass index, blood pressure, cholesterol, triglycerides, and insulin levels were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Infant subcutaneous fat measures were not associated with childhood blood pressure, triglycerides, or insulin levels. A 1\u2010standard\u2010deviation score (SDS) higher total subcutaneous fat at 1.5 months was, independently of body mass index, associated with lower low\u2010density lipoprotein (LDL)\u2010cholesterol levels at 6 years. In contrast, a 1\u2010SDS higher total subcutaneous fat at 24 months was associated with higher total\u2010cholesterol [difference 0.13 (95% confidence interval (CI) 0.03, 0.23) SDS] and LDL\u2010cholesterol levels [difference 0.12 (95% CI 0.02, 0.21) SDS] at 6 years. There were no associations of central\u2010to\u2010total subcutaneous fat ratio with childhood cholesterol levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that infant total subcutaneous fat is weakly associated with cholesterol levels at school\u2010age. Further studies are needed to assess the long\u2010term cardiometabolic consequences of infant body fat.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21343","type":"journal-article","created":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T08:01:36Z","timestamp":1452067296000},"page":"424-429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Subcutaneous fat mass in infancy and cardiovascular risk factors at school\u2010age: The generation <scp>R<\/scp> study"],"prefix":"10.1002","volume":"24","author":[{"given":"Susana","family":"Santos","sequence":"first","affiliation":[{"name":"EPI\u2010Unit Institute of Public Health, University of Porto Porto Portugal"},{"name":"The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romy","family":"Gaillard","sequence":"additional","affiliation":[{"name":"The Generation R 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