{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:02:04Z","timestamp":1785304924085,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T00:00:00Z","timestamp":1455062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate the risk of preterm preeclampsia in primiparous women by pre\u2010pregnancy obesity class.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of primiparous women with singleton gestations was performed for deliveries from January 2003 to April 2014. Cases were stratified by delivery occurring either at\u2009\u2265\u200937 weeks or\u2009&lt;\u200937 weeks. Pre\u2010pregnancy maternal obesity was defined as a body mass index (BMI)\u2009\u2265\u200930 kg\/m<jats:sup>2<\/jats:sup>. World Health Organization criteria were used to define BMI class of obesity. Multinomial logistic regression modeling estimated the association between term and preterm preeclampsia and pre\u2010pregnancy obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 28,361 women with complete pre\u2010pregnancy BMI data, 2,588 women (9.1%) had a diagnosis of preeclampsia. Women who developed preeclampsia prior to 37 weeks (<jats:italic>n<\/jats:italic>\u2009=\u2009784) were more likely to be women with obesity compared to women who developed preeclampsia after 37 weeks (33.1% vs. 25.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.0001). Compared to normal\u2010weight women without preeclampsia, the risk of preterm preeclampsia increased proportionally with pre\u2010pregnancy obesity class, with women with a BMI\u2009\u2265\u200940 kg\/m<jats:sup>2<\/jats:sup> having the greatest risk (RR 5.23, 95% CI: 3.86\u20107.09, <jats:italic>P<\/jats:italic> &lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risk of preterm preeclampsia increased significantly as the severity of maternal pre\u2010pregnancy obesity increased. Reduction in maternal pre\u2010pregnancy BMI may be protective in mitigating such risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21412","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T04:19:51Z","timestamp":1455164391000},"page":"1226-1229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Pre\u2010pregnancy maternal obesity and the risk of preterm preeclampsia in the American primigravida"],"prefix":"10.1002","volume":"24","author":[{"given":"Omar M.","family":"Young","sequence":"first","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology Washington University in St. Louis School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxanna","family":"Twedt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences Magee\u2010Womens Hospital\/University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet M.","family":"Catov","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences Magee\u2010Womens Hospital\/University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"},{"name":"Department of Epidemiology University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.whi.2010.05.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00143-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.20"},{"key":"e_1_2_6_5_1","first-page":"1122","article-title":"Hypertension in pregnancy: executive summary","volume":"122","author":"Roberts JM","year":"2014","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000254119.99660.e7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340802303349"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.EDE.0000059921.71494.D1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.08.019"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0b013e3182331028"},{"key":"e_1_2_6_11_1","unstructured":"Obesity: Preventing and Managing the Global Epidemic. 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Available at:http:\/\/quickfacts.census.gov\/qfd\/states\/42000.html accessed on 14\/10\/2015."}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.21412","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.21412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:39:46Z","timestamp":1695508786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.21412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,10]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1002\/oby.21412"],"URL":"https:\/\/doi.org\/10.1002\/oby.21412","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,10]]},"assertion":[{"value":"2015-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}