{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:12:25Z","timestamp":1781788345590,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01DK091338\u201001A1 and 3R01DK091338\u201002S1)"],"award-info":[{"award-number":["1R01DK091338\u201001A1 and 3R01DK091338\u201002S1)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Obesity, particularly child obesity, is one of the most common public health problems in the world and raises the risk of end\u2010stage renal disease. Zinc (Zn) is essential for multiple organs in terms of normal structure and function; however, effects of Zn deficiency or supplementation among young individuals with obesity have not been well studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Weaned mice were fed high\u2010fat diets (HFD) with varied contents of Zn (Zn deficient, adequate, and supplemented) for 3 or 6 months. This study examined associations between renal pathogenesis and dietary Zn levels, specifically assessing inflammatory pathways by utilizing P38 MAPK inhibitor SB203580.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HFD feeding induced typical syndromes of obesity\u2010related renal disorders, which worsened by Zn marginal deficiency. The progression of obesity\u2010related renal disorders was delayed by Zn supplementation. HFD induced renal inflammation, reflected by increased P38 MAPK phosphorylation along with increases of inflammatory cytokines MCP\u20101, IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1. P38 MAPK inhibition prevented renal pathological changes in mice fed with HFD and HFD\/Zn deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>P38 MAPK mediated the renal inflammatory responses, which played a central role in the pathogenesis of HFD\u2010induced renal disorders. Zn could delay the progression of obesity\u2010related kidney disease by down\u2010regulating P38 MAPK\u2010mediated inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21463","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T13:52:09Z","timestamp":1459432329000},"page":"1244-1256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Zinc delays the progression of obesity\u2010related glomerulopathy in mice via down\u2010regulating <scp>P<\/scp>38 <scp>MAPK<\/scp>\u2010mediated inflammation"],"prefix":"10.1002","volume":"24","author":[{"given":"Manyu","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Nephrology The Second Hospital of Jilin University Changchun Jilin China"},{"name":"Department of Pediatrics The University of Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Second Hospital of Jilin University Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Louisville Kentucky USA"},{"name":"The First Hospital of Jilin University Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Payne","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Louisville Kentucky USA"},{"name":"Department of Internal Medicine The Marshall University Joan C. 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