{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:48:55Z","timestamp":1789541335948,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T00:00:00Z","timestamp":1464134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The epidemiology of post\u2010gastric bypass surgery hypoglycemia (PGBH) is incompletely understood. This study aimed to evaluate the risk of PGBH among nondiabetic patients and associated factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort study of nondiabetic patients who underwent Roux\u2010en\u2010Y gastric bypass (RYGB) was conducted. PGBH was defined by any postoperative record of glucose\u2009&lt;\u200960 mg\/dL, diagnosis of hypoglycemia, or any medication use for treatment of PGBH. Kaplan\u2010Meier analysis was used to describe PGBH occurrence, log\u2010rank tests, and Cox regression to examine associated factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1,206 eligible patients, 86% were female with mean age of 43.7 years, mean preoperative BMI of 48.7 kg\/m<jats:sup>2<\/jats:sup>, and a mean follow\u2010up of 4.8 years. The cumulative incidence of hypoglycemia at 1 and 5 years post\u2010RYGB was 2.7% and 13.3%, respectively. Incidence of PGBH was identified in 158 patients and was associated with lower preoperative BMI (<jats:italic>P<\/jats:italic>\u2009=\u20090.048), lower preoperative HbA1c (<jats:italic>P<\/jats:italic>\u2009=\u20090.012), and higher 6\u2010month percent of excess body weight loss (%EWL) (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). A lower preoperative HbA1c (HR\u2009=\u20091.73, <jats:italic>P<\/jats:italic>\u2009=\u20090.0034)  and higher 6\u2010month %EWL (HR\u2009=\u20091.96, <jats:italic>P<\/jats:italic>\u2009=\u20090.0074) remained independently correlated with increased risk for PGBH in multi\u2010regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The 5\u2010year incidence of PGBH among nondiabetic individuals was 13.3% and was associated with a lower preoperative HbA1c and greater weight loss at 6 months following surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21479","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T07:30:26Z","timestamp":1464247826000},"page":"1342-1348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Risk of post\u2010gastric bypass surgery hypoglycemia in nondiabetic individuals: A single center experience"],"prefix":"10.1002","volume":"24","author":[{"given":"Clare J.","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes &amp; Metabolism, Department of Medicine the Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Craig","family":"Wood","sequence":"additional","affiliation":[{"name":"Geisinger Obesity Research Institute Geisinger Clinic Danville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Lazo","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine the Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd T.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes &amp; Metabolism, Department of Medicine the Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne M.","family":"Clark","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine the Johns Hopkins University Baltimore Maryland 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