{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:03:40Z","timestamp":1779235420642,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T00:00:00Z","timestamp":1464134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Intramural Research Program of the National Institutes of Health"},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the concurrent relationships between human plasma erythropoietin concentrations and energy expenditure (EE), body composition, plasma leptin concentrations, and associations with weight change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Plasma to measure erythropoietin and leptin; data for body composition; 24\u2010h EE measured in a whole\u2010room calorimeter; and 75 g oral glucose tolerance testing were available from 109 full\u2010heritage Pima Indians (55% male) from a larger study designed to understand the causes of obesity. Seventy\u2010nine subjects had data for weight at a later visit (mean follow\u2010up<jats:italic>=<\/jats:italic>4.3\u2009\u00b1\u20091.9 years) to calculate percent weight change per year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Erythropoietin, adjusted for covariates, correlated with 24\u2010h EE (<jats:italic>r =<\/jats:italic>0.26,<jats:italic>P =<\/jats:italic>0.007), sleeping EE (<jats:italic>r =<\/jats:italic>0.29,<jats:italic>P =<\/jats:italic>0.003), fat\u2010free mass (<jats:italic>r =<\/jats:italic>0.19,<jats:italic>P =<\/jats:italic>0.05), and fat mass (<jats:italic>r =<\/jats:italic>0.27,<jats:italic>P =<\/jats:italic>0.005), but not insulin or glucose measures. The association of erythropoietin with 24\u2010h EE was fully mediated by fat\u2010free mass. Erythropoietin associated with leptin in women (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.36,<jats:italic>P =<\/jats:italic>0.01), but not in men (<jats:italic>P =<\/jats:italic>0.9), independently from fat mass. The association of erythropoietin with percent weight change per year was in opposing directions (interaction:<jats:italic>P =<\/jats:italic>0.002) in males (<jats:italic>r =<\/jats:italic>\u22120.35,<jats:italic>P =<\/jats:italic>0.02) versus females (<jats:italic>r =<\/jats:italic>0.37,<jats:italic>P =<\/jats:italic>0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010hematopoietic endogenous erythropoietin action may be involved in body weight regulation in opposing directions in men and women, i.e., weight loss in men and weight gain in women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21537","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T11:29:09Z","timestamp":1464175749000},"page":"1530-1536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Non\u2010hematopoietic effects of endogenous erythropoietin on lean mass and body weight regulation"],"prefix":"10.1002","volume":"24","author":[{"given":"Martin","family":"Reinhardt","sequence":"first","affiliation":[{"name":"Obesity and Diabetes Clinical Research Section Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Phoenix Arizona USA"},{"name":"Department of Diagnostic and Interventional Radiology University of Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumyadeep","family":"Dey","sequence":"additional","affiliation":[{"name":"Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance","family":"Tom Noguchi","sequence":"additional","affiliation":[{"name":"Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Krakoff","sequence":"additional","affiliation":[{"name":"Obesity and Diabetes Clinical Research Section Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie S.","family":"Thearle","sequence":"additional","affiliation":[{"name":"Obesity and Diabetes Clinical Research Section Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of 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