{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:15:56Z","timestamp":1791908156266,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T00:00:00Z","timestamp":1465862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Danish Agency for Science, Technology and Innovation and the Danish Research Foundation as well as the Technical University of Denmark"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>In this study, KBP\u2010042, a dual amylin\u2010 and calcitonin\u2010receptor agonist, was investigated as a treatment of obesity and insulin resistance in five different doses (0.625 \u00b5g\/kg\u201310 \u00b5g\/kg) compared with saline\u2010treated and pair\u2010fed controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rats with obesity received daily s.c. administrations for 56 days, and glucose tolerance was assessed after one acute injection, 3 weeks of treatment, and again after 7 weeks of treatment. To assess the effect on insulin sensitivity, rats received 5 \u00b5g\/kg KBP\u2010042 for 21 days before hyperinsulinemic\u2013euglycemic clamp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>KBP\u2010042 induced a sustained weight loss of up to 20% without any significant weight reduction in the pair\u2010fed groups. Decreases in adipose tissues and lipid deposition in the liver were observed, while plasma adiponectin was increased and plasma leptin levels were decreased. Acute administration of KBP\u2010042 led to impaired glucose tolerance and increased plasma lactate, while this diabetogenic effect was reversed by chronic treatment. Finally, assessment of insulin sensitivity using the hyperinsulinemic\u2013euglycemic clamp showed that KBP\u2010042 increased the glucose infusion rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study indicates that KBP\u2010042 combines two highly relevant features, namely weight loss and insulin sensitivity, and is thus an excellent candidate for chronic treatment of obesity and insulin resistance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21563","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T11:36:50Z","timestamp":1465904210000},"page":"1712-1722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The dual amylin\u2010 and calcitonin\u2010receptor agonist KBP\u2010042 increases insulin sensitivity and induces weight loss in rats with obesity"],"prefix":"10.1002","volume":"24","author":[{"given":"Sara Toftegaard","family":"Hjuler","sequence":"first","affiliation":[{"name":"Nordic Bioscience Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Gydesen","sequence":"additional","affiliation":[{"name":"Nordic Bioscience Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Vietz","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Nordic Bioscience Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen Lund Kj\u00e6r","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Nordic Bioscience Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars I.","family":"Hellgren","sequence":"additional","affiliation":[{"name":"Department of Systems Biology Technical University of Denmark  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Asser","family":"Karsdal","sequence":"additional","affiliation":[{"name":"Nordic Bioscience Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Nordic Bioscience Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,14]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"WHO.A Comprehensive Global Monitoring Framework Including Indicators and a Set of Voluntary Global Targets for the Prevention and Control of Noncommunicable Diseases. 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