{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:36:17Z","timestamp":1791920177278,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T00:00:00Z","timestamp":1474675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Loma Linda University School of Pharmacy and Medifast, Inc."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the effects of phentermine combined with a meal replacement program on weight loss and food cravings and to investigate the relationship between food cravings and weight loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a 12\u2010week randomized, double\u2010blind, placebo\u2010controlled clinical trial, 77 adults with obesity received either phentermine or placebo. All participants were provided Medifast\n                      <jats:sup>\u00ae<\/jats:sup>\n                      meal replacements, were instructed to follow the Take Shape for Life\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Optimal Weight 5&amp;1 Plan for weight loss, and received lifestyle coaching in the\n                      <jats:italic>Habits of Health<\/jats:italic>\n                      program. The Food Craving Inventory and the General Food Cravings State and Trait Questionnaires were used to measure food cravings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The phentermine group lost 12.1% of baseline body weight compared with 8.8% in the placebo group. Cravings for all food groups decreased in both groups; however, there was a greater reduction in cravings for fats and sweets in the phentermine group compared with the placebo group. Percent weight loss correlated significantly with reduced total food cravings (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.332,\n                      <jats:italic>P =<\/jats:italic>\n                      0.009), cravings for sweets (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.412,\n                      <jats:italic>P &lt;<\/jats:italic>\n                      0.000), and state food cravings (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.320,\n                      <jats:italic>P =<\/jats:italic>\n                      0.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both phentermine combined with a meal replacement program and meal replacements alone significantly reduced body weight and food cravings; however, the addition of phentermine enhanced these effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.21649","type":"journal-article","created":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T02:54:08Z","timestamp":1474685648000},"page":"2344-2350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Effects of a meal replacement system alone or in combination with phentermine on weight loss and food cravings"],"prefix":"10.1002","volume":"24","author":[{"given":"Christina P.","family":"Moldovan","sequence":"first","affiliation":[{"name":"Department of Psychology, School of Behavioral Health Loma Linda University Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby J.","family":"Weldon","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Administrative Sciences, School of Pharmacy Loma Linda University Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha S.","family":"Daher","sequence":"additional","affiliation":[{"name":"Department of Allied Health Studies, School of Allied Health Professions Loma Linda University Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise E.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Allied Health Professions Loma Linda University Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise L.","family":"Bellinger","sequence":"additional","affiliation":[{"name":"Department of Pathology and Human Anatomy Loma Linda University Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee S.","family":"Berk","sequence":"additional","affiliation":[{"name":"Department of Allied Health Studies, School of Allied Health Professions Loma Linda University Loma Linda California USA"},{"name":"Department of Physical Therapy, School of Allied Health Professions Loma Linda University Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyson C.","family":"Herm\u00e9","sequence":"additional","affiliation":[{"name":"Department of Psychology, School of Behavioral Health Loma Linda University Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L.","family":"Ar\u00e9chiga","sequence":"additional","affiliation":[{"name":"Department of Psychology, School of Behavioral Health Loma Linda University Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willie L.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Administrative Sciences, School of Pharmacy Loma Linda University Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren 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