{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:02:26Z","timestamp":1788667346374,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T00:00:00Z","timestamp":1478044800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["K23 RR020038\u201001"],"award-info":[{"award-number":["K23 RR020038\u201001"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Increased liver fat and type 2 diabetes are prevalent in women with polycystic ovarian syndrome (PCOS) and cause excess mortality, yet little is known about their development during adolescence. The objective of this study was to measure hepatic steatosis and related metabolic contributors in girls with obesity, with and without PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nondiabetic adolescents with obesity, 41 with PCOS (PCOS; age 15.0 [13.0\u201016.0] years, BMI 35.2\u2009\u00b1\u20090.61 kg\/m<jats:sup>2<\/jats:sup>) and 30 without PCOS (OB; age 14.5 [13.0\u201017.0], BMI 33.2\u2009\u00b1\u20091.8), were studied. Visceral and liver fat were assessed with MRI. Serum measures included androgens and 16:1 and 18:1 N7 fatty acids specific to <jats:italic>de novo<\/jats:italic> lipogenesis. Adipose, hepatic, and peripheral insulin sensitivity (IS) were assessed with a four\u2010phase hyperinsulinemic\u2010euglycemic clamp with isotope tracers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010nine percent of the PCOS group had hepatic steatosis versus fourteen percent of the OB group (<jats:italic>P =<\/jats:italic> 0.02), and the PCOS group had higher N7 (43\u2009\u00b1\u20094 vs. 29\u2009\u00b1\u20095 nmol\/g; <jats:italic>P =<\/jats:italic> 0.02). Peripheral IS was lower in PCOS (9.4 [7.2\u201012.3] vs. 14.5 [13.1\u201018.05 mg\/lean kg\/min]; <jats:italic>P &lt;<\/jats:italic> 0.001) as was hepatic (<jats:italic>P =<\/jats:italic> 0.006) and adipose IS (<jats:italic>P =<\/jats:italic> 0.005). Percent liver fat correlated with N7 (<jats:italic>R<\/jats:italic>\u2009=\u20090.46, <jats:italic>P =<\/jats:italic> 0.02) and visceral fat (<jats:italic>R<\/jats:italic>\u2009=\u20090.42, <jats:italic>P &lt;<\/jats:italic> 0.001), not androgens or peripheral IS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nearly 50% of nondiabetic girls with PCOS and obesity have hepatic steatosis, which relates to visceral fat and lipogenesis, but not to IS or androgens.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21651","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T05:29:23Z","timestamp":1478064563000},"page":"2399-2406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Hepatic Steatosis is Common in Adolescents with Obesity and <scp>PCOS<\/scp> and Relates to <i>De Novo<\/i> Lipogenesis but not Insulin Resistance"],"prefix":"10.1002","volume":"24","author":[{"given":"Melanie","family":"Cree\u2010Green","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Endocrinology University of Colorado Anschutz Medical Campus Aurora Colorado USA"},{"name":"Department of Pediatric Endocrinology Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan C.","family":"Bergman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory V.","family":"Coe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Endocrinology University of Colorado Anschutz Medical Campus Aurora Colorado 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