{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:24:11Z","timestamp":1772832251834,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T00:00:00Z","timestamp":1478044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["R18 HL076441"],"award-info":[{"award-number":["R18 HL076441"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Translational Science Center of Wake Forest University, and Wake Forest Older Americans Independence Center","award":["P3021332"],"award-info":[{"award-number":["P3021332"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to investigate whether structural brain phenotypes could be used to predict weight loss success following behavioral interventions in older adults with overweight or obesity and cardiometabolic dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A support vector machine with a repeated random subsampling validation approach was used to classify participants into the upper and lower halves of the weight loss distribution following 18 months of a weight loss intervention. Predictions were based on baseline brain gray matter and white matter volume from 52 individuals who completed the intervention and a magnetic resonance imaging session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The support vector machine resulted in an average classification accuracy of 72.62% based on gray matter and white matter volume. A receiver operating characteristic analysis indicated that classification performance was robust based on an area under the curve of 0.82.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings suggest that baseline brain structure was able to predict weight loss success following 18 months of treatment. The identification of brain structure as a predictor of successful weight loss was an innovative approach to identifying phenotypes for responsiveness to intensive lifestyle interventions. This phenotype could prove useful in future research focusing on the tailoring of treatment for weight loss.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21652","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T05:04:00Z","timestamp":1478063040000},"page":"2475-2480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Baseline gray\u2010 and white\u2010matter volume predict successful weight loss in the elderly"],"prefix":"10.1002","volume":"24","author":[{"given":"Fatemeh","family":"Mokhtari","sequence":"first","affiliation":[{"name":"Department of Radiology, Laboratory for Complex Brain Networks Wake Forest University School of Medicine Winston Salem North Carolina USA"},{"name":"Department of Biomedical Engineering, Virginia Tech\u2010Wake Forest University School of Biomedical Engineering and Sciences Winston Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brielle M.","family":"Paolini","sequence":"additional","affiliation":[{"name":"Department of Radiology, Laboratory for Complex Brain Networks Wake Forest University School of Medicine Winston Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan H.","family":"Burdette","sequence":"additional","affiliation":[{"name":"Department of Radiology, Laboratory for Complex Brain Networks Wake Forest University School of Medicine Winston Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony P.","family":"Marsh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Virginia Tech\u2010Wake Forest University School of Biomedical Engineering and Sciences Winston Salem North Carolina USA"},{"name":"Translational Science Center Wake Forest University Winston Salem North Carolina USA"},{"name":"Department of Health and Exercise Science Wake Forest University Winston Salem North Carolina USA"},{"name":"Department of Geriatric Medicine Wake Forest University Winston Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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