{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:09:27Z","timestamp":1792609767004,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES022981"],"award-info":[{"award-number":["ES022981"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES021372"],"award-info":[{"award-number":["ES021372"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010DK\u201046200"],"award-info":[{"award-number":["P30\u2010DK\u201046200"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Associations of overall and regional body fat measured by dual\u2010energy X\u2010ray absorptiometry with total and cause\u2010specific mortality in the National Health and Nutrition Examination Survey (NHANES) 1999\u20102006 were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 9,471 participants (\u226520 years) free of major chronic diseases at baseline. Death information was obtained from the National Death Index (mean follow\u2010up duration: 8.8 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 682 participants died after 12 months since baseline, with 206 and 170 deaths attributed to cardiovascular diseases (CVD) and cancer, respectively. The second quartile of fat mass percentages (FM%) was used as the reference to account for potential nonlinearity. In the multivariate\u2010adjusted model, participants in the highest quartile of total FM% had increased total mortality; hazard ratio (HR; 95% confidence interval, 95% CI) was 1.48 (1.07\u20102.04; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Higher total and trunk FM%, but not leg FM%, were significantly associated with an increased CVD mortality; HRs (95% CIs) in the highest quartiles of total, trunk, and leg FM% were 2.24 (1.17\u20104.31), 1.93 (1.02\u20103.66), and 1.50 (0.77\u20102.94), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher total body fat was associated with increased total mortality in U.S. adults. Higher total and trunk fat contents were also associated with increased CVD mortality, although fat accumulation in the lower body was not an independent predictor of mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21659","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T09:16:46Z","timestamp":1474881406000},"page":"2414-2421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Total and regional adiposity measured by dual\u2010energy X\u2010ray absorptiometry and mortality in NHANES 1999\u20102006"],"prefix":"10.1002","volume":"24","author":[{"given":"Geng","family":"Zong","sequence":"first","affiliation":[{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zefeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division for Heart Disease and Stroke Prevention Centers for Disease Control and Prevention Atlanta, Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanhe","family":"Yang","sequence":"additional","affiliation":[{"name":"Division for Heart Disease and Stroke Prevention Centers for Disease Control and Prevention Atlanta, Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank B.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health Boston Massachusetts USA"},{"name":"Department of Medicine, Channing Division of Network Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health Boston Massachusetts USA"},{"name":"Department of Medicine, Channing Division of Network Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"2008 Oxford University Press New York NY FB. 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