{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:45:16Z","timestamp":1778816716114,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Foundation for Research Science and Technology, Health Research Council and Auckland District Health Board Charitable Trust in New Zealand"},{"name":"Premier's Science and Research Fund, Government of South Australia in Australia"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether the <jats:italic>FTO<\/jats:italic> rs9939609 single nucleotide polymorphism (SNP), which is a risk factor for obesity and vascular diseases, is also associated with pregnancy complications including pre\u2010eclampsia, gestational hypertension, small for gestational age pregnancy (SGA), and spontaneous preterm birth (sPTB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2010control study of 1,741 nulliparous Caucasian women, their partners, and infants was conducted. DNA was extracted from peripheral blood or saliva from parents and cord blood from infants and genotyped using the Sequenom MassARRAY system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of maternal and infant AA genotype of <jats:italic>FTO<\/jats:italic> rs9939609 was increased in the SGA group compared with the uncomplicated pregnancy group (19.2% vs. 13.4%, OR\u2009=\u20091.7, 95% CI\u2009=\u20091.1\u20102.6, <jats:italic>P =<\/jats:italic> 0.02 and 24.6% vs. 12.5%, OR\u2009=\u20092.7, 95% CI\u2009=\u20091.6\u20104.6, <jats:italic>P =<\/jats:italic> 0.0002). The prevalence of maternal and infant AA genotype of <jats:italic>FTO<\/jats:italic> rs9939609 was also increased in the sPTB group compared with the uncomplicated pregnancy group (20.8% vs. 13.4%, OR\u2009=\u20092.1, 95% CI\u2009=\u20091.2\u20103.8, <jats:italic>P =<\/jats:italic> 0.009 and 20.0% vs. 12.5%, OR\u2009=\u20092.4, 95% CI\u2009=\u20091.0\u20105.3, <jats:italic>P =<\/jats:italic> 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The maternal and infant AA genotype of the obesity associated <jats:italic>FTO<\/jats:italic> rs9939609 SNP associates with increased risk for SGA and sPTB. This SNP may be important in predicting the risk of these pregnancy complications and subsequent vascular diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21662","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T15:29:16Z","timestamp":1477063756000},"page":"2600-2607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The obesity associated <scp><i>FTO<\/i><\/scp> gene variant and the risk of adverse pregnancy outcomes: Evidence from the <scp>SCOPE<\/scp> study"],"prefix":"10.1002","volume":"24","author":[{"given":"Prabha H.","family":"Andraweera","sequence":"first","affiliation":[{"name":"Discipline of Obstetrics and Gynaecology Adelaide Medical School, Robinson Research Institute, The University of Adelaide Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustaaf 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