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Fat indices determined by anthropometry and computed tomography scans and clinical biochemical measurements were collected for association analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LGR4 A750T was significantly correlated with waist circumference (<jats:italic>P =<\/jats:italic> 0.030) and waist\u2010to\u2010height ratio (<jats:italic>P &lt;<\/jats:italic> 0.001) in the young cohort (<jats:italic>N =<\/jats:italic> 594) and with waist\u2010to\u2010hip ratio (<jats:italic>P =<\/jats:italic> 0.013) in the community population (<jats:italic>N =<\/jats:italic> 1067). Combined analysis showed a significant correlation of the variant with waist circumference (<jats:italic>P &lt;<\/jats:italic> 0.001) and waist\u2010to\u2010hip ratio (<jats:italic>P =<\/jats:italic> 0.021). Moreover, the variant had a remarkable correlation with abdominal visceral fat area (<jats:italic>P =<\/jats:italic> 0.004) and was associated with 2\u2010h plasma insulin (<jats:italic>P =<\/jats:italic> 0.009) and the Matsuda index (<jats:italic>P =<\/jats:italic> 0.027) after an oral glucose tolerance test in young subjects with obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The LGR4 A750T variant may contribute to central obesity characterized by abdominal visceral fat accumulation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21704","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T13:02:33Z","timestamp":1481115753000},"page":"252-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Association of a gain\u2010of\u2010function variant in <i>LGR4<\/i> with central obesity"],"prefix":"10.1002","volume":"25","author":[{"given":"Yaoyu","family":"Zou","sequence":"first","affiliation":[{"name":"Laboratory of Endocrinology and Metabolism Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences &amp; Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinglu","family":"Ning","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrinology and Metabolism Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences &amp; Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Shi","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Medical Genomes, Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, China National Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maopei","family":"Chen","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Medical Genomes, Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, China National Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ding","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Medical Genomes, Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, China National Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Huang","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Medical Genomes, Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, China National Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Kauderer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Center for Global Cardiometabolic Health, School of Public Health; Department of Medicine (Endocrinology) The Warren Alpert Medical School, Brown University Providence Rhode Island 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