{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:42:28Z","timestamp":1768826548700,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T00:00:00Z","timestamp":1482451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["04\/198"],"award-info":[{"award-number":["04\/198"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["GT084"],"award-info":[{"award-number":["GT084"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001590","name":"Health Research Board","doi-asserted-by":"publisher","award":["CSA\/2007\/2"],"award-info":[{"award-number":["CSA\/2007\/2"]}],"id":[{"id":"10.13039\/501100001590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare early pregnancy clinical and biomarker risk factors for later development of preeclampsia between women with obesity (body mass index, BMI \u226530 kg\/m<jats:sup>2<\/jats:sup>) and those with a normal BMI (20\u201325 kg\/m<jats:sup>2<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 3,940 eligible nulliparous women from the Screening for Pregnancy Endpoints (SCOPE) study, a total of 53 biomarkers of glucose and lipid metabolism, placental function, and known markers of preeclampsia were measured at 14 to 16 weeks' gestation. Logistic regression was performed to identify clinical and biomarker risk factors for preeclampsia in women with and without obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 834 women with obesity and 3,106 with a normal BMI, 77 (9.2%) and 105 (3.4%) developed preeclampsia, respectively. In women with obesity, risk factors included a family history of thrombotic disease, low plasma placental growth factor, and higher uterine artery resistance index at 20 weeks. In women with a normal BMI, a family history of preeclampsia or gestational hypertension, mean arterial blood pressure, plasma endoglin and cystatin C, and uterine artery resistance index were associated with preeclampsia, while high fruit intake was protective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with obesity and a normal BMI have different early pregnancy clinical and biomarker risk factors for preeclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21715","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T19:28:59Z","timestamp":1482607739000},"page":"460-467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Clinical and biochemical factors associated with preeclampsia in women with obesity"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8076-4275","authenticated-orcid":false,"given":"Matias C.","family":"Vieira","sequence":"first","affiliation":[{"name":"Division of Women's Health Women's Health Academic Centre, King's College London and King's Health Partners London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucilla","family":"Poston","sequence":"additional","affiliation":[{"name":"Division of Women's Health Women's Health Academic Centre, King's College London and King's Health Partners London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Fyfe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences University of Auckland Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Gillett","sequence":"additional","affiliation":[{"name":"Division of Women's Health Women's Health Academic Centre, King's College London and King's Health Partners London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise C.","family":"Kenny","sequence":"additional","affiliation":[{"name":"The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital Wilton Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire T.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Discipline of Obstetrics and Gynaecology Robinson Research Institute, University of Adelaide Adelaide South Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip N.","family":"Baker","sequence":"additional","affiliation":[{"name":"College of Medicine, Biological Sciences &amp; Psychology University of Leicester  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny E.","family":"Myers","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology, School of Medical Sciences The Faculty of Biology Medicine and Health, Manchester Academic Heath Science Centre, University of Manchester  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Leeds Institute of Biomedical &amp; Clinical Sciences, University of Leeds  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley M.","family":"McCowan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences University of Auckland Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn A.","family":"North","sequence":"additional","affiliation":[{"name":"Division of Women's Health Women's Health Academic Centre, King's College London and King's Health Partners London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dharmintra","family":"Pasupathy","sequence":"additional","affiliation":[{"name":"Division of Women's Health Women's Health Academic Centre, King's College London and King's Health Partners London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the SCOPE Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.18.2146"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.978279"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.10.047"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17987-2"},{"key":"e_1_2_7_7_1","first-page":"CD001059","article-title":"Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems","volume":"6","author":"Hofmeyr GJ","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60712-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d1875"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341264"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031884"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090640"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200411000-00021"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03578"},{"key":"e_1_2_7_15_1","unstructured":"McCowanL NorthRA TaylorR.Screening for pregnancy endpoints: preeclampsia growth restricted baby and spontaneous preterm birth. 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