{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:45:35Z","timestamp":1790185535398,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the short\u2010term tolerability of lorcaserin alone or with two dose regimens of phentermine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a 12\u2010week, randomized, double\u2010blind, pilot safety study of <jats:italic>N<\/jats:italic>\u2009=\u2009238 nondiabetic patients with obesity or overweight with \u22651 comorbidity randomized to lorcaserin 10 mg twice daily (BID; LOR BID) alone or with phentermine 15 mg once daily (QD; LOR BID+PHEN QD) or 15 mg twice daily (LOR BID+PHEN BID). Patients reporting\u2009\u2265\u20091 of 9 potentially serotonergic adverse events (AEs), mean weight loss (WL), and \u22655% WL are reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>N<\/jats:italic>\u2009=\u2009238 were randomized, and <jats:italic>N<\/jats:italic>\u2009=\u2009235 were treated. <jats:italic>N<\/jats:italic>\u2009=\u200994 reported potentially serotonergic AEs: 37.2% LOR BID, 42.3% LOR BID+PHEN QD, and 40.5% LOR BID+PHEN BID. AEs leading to discontinuation were reported approximately twice as often in the LOR BID+PHEN BID group versus the LOR BID group. Mean WL was 3.5\u2009kg\/3.3%, 7.0\u2009kg\/6.7%, and 7.6\u2009kg\/7.2% for LOR BID, LOR BID+PHEN QD, and LOR BID+PHEN BID, respectively. At least 5% WL was achieved by 28.2% LOR BID, 59.0% LOR BID+PHEN QD (<jats:italic>P<\/jats:italic>\u2009=\u20090.0002 vs. LOR BID), and 70.9% LOR BID+PHEN BID (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 vs. LOR BID) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Phentermine added to lorcaserin enhanced short\u2010term weight loss but did not increase incidence of potentially serotonergic AEs; however, phentermine twice daily increased discontinuation compared to both lorcaserin alone and lorcaserin plus phentermine once daily.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21811","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T05:05:55Z","timestamp":1493096755000},"page":"857-865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Coadministration of lorcaserin and phentermine for weight management: A 12\u2010week, randomized, pilot safety study"],"prefix":"10.1002","volume":"25","author":[{"given":"Steven R.","family":"Smith","sequence":"first","affiliation":[{"name":"Center for the Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute Orlando Florida USA"},{"name":"Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Timothy","family":"Garvey","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences University of Alabama at Birmingham, and the Birmingham VA Medical Center, Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank L.","family":"Greenway","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center Louisiana State University System Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Zhou","sequence":"additional","affiliation":[{"name":"Eisai Medical and Scientific Affairs, Eisai Inc. Woodcliff Lake New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi","family":"Fain","sequence":"additional","affiliation":[{"name":"Formerly Eisai Inc. Woodcliff Lake New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Pilson","sequence":"additional","affiliation":[{"name":"Formerly Eisai Inc. Woodcliff Lake New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Scripps Clinic La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis J.","family":"Aronne","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medical College New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,25]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"S3","article-title":"Pathophysiology, epidemiology, and assessment of obesity in adults","volume":"63","author":"Skolnik NS","year":"2014","journal-title":"J Fam Pract"},{"key":"e_1_2_7_3_1","first-page":"S15","article-title":"Principles and nonpharmacologic management of obesity in adults","volume":"63","author":"Kushner RF","year":"2014","journal-title":"J Fam Pract"},{"key":"e_1_2_7_4_1","first-page":"S21","article-title":"The pharmacological and surgical management of adults with obesity","volume":"63","author":"Ryan DH","year":"2014","journal-title":"J Fam Pract"},{"key":"e_1_2_7_5_1","first-page":"S1","article-title":"2013 Guidelines (2013) for managing overweight and obesity in adults","volume":"22","author":"Jensen MD","year":"2014","journal-title":"Obesity (Silver Spring)"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.461"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.478"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.009621"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.330"},{"key":"e_1_2_7_10_1","unstructured":"BELVIQ (lorcaserin hydrochloride) US Prescribing Information. 2014. 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