{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:30:53Z","timestamp":1789421453042,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Obesity has been associated with various malignancies, but a clear association between overweight and myeloproliferative neoplasms (MPN) has not been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study assessed the association between adolescent obesity and future risk for MPN. Data on 2,516,256 Israeli adolescents, who underwent a compulsory general health examination at ages 16 to 19, between 1967 and 2011, were linked to the National Cancer Registry in this nationwide, population\u2010based cohort study. Cox proportional hazards models were used to estimate the hazard ratio (HR) for MPN associated with BMI measured at adolescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow\u2010up of 19.86\u2009\u00b1\u200912.15 years reflected 49,977,521 person years, during which 433 examinees developed MPN, primarily chronic myelogenous leukemia, polycythemia vera, and essential thrombocythemia. Obesity (BMI\u2009\u2265\u200995th percentile) in adolescence significantly predicted increased risk of MPN with HR (adjusted for sex) of 1.81 (95% confidence interval 1.13\u20102.92,<jats:italic>P<\/jats:italic>\u2009=\u20090.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adolescent obesity might be related to an increased incidence of myeloproliferative neoplasms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21863","type":"journal-article","created":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T04:20:36Z","timestamp":1494649236000},"page":"1187-1190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Obesity and related risk of myeloproliferative neoplasms among Israeli adolescents"],"prefix":"10.1002","volume":"25","author":[{"given":"Adi","family":"Leiba","sequence":"first","affiliation":[{"name":"IDF Medical Corps Tel Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Mount Auburn Hospital, Department of Medicine, Harvard Medical School Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Duek","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Department of Hematology and Bone Marrow Transplant, Sheba Medical Center Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon","family":"Afek","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Derazne","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merav","family":"Leiba","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Department of Hematology and Bone Marrow Transplant, Sheba Medical Center Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1182\/blood.V6.4.372.372","article-title":"Some speculations on the myeloproliferative syndromes [editorial]","volume":"6","author":"Dameshek W","year":"1951","journal-title":"Blood"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2015.06.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.334"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22212"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-143602"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28492"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.159"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-03-2135"},{"key":"e_1_2_6_10_1","unstructured":"Israel Ministry of Health. Israel National Cancer Registry.https:\/\/www.health.gov.il\/English\/MinistryUnits\/HealthDivision\/Icdc\/Icr\/Pages\/default.aspx. Accessed January 7 2017."},{"key":"e_1_2_6_11_1","unstructured":"Israel Central Bureau of Statistics.Characterization and classification of local authorities by the socio\u2010economic level of the population 2006. Jerusalem 2009.http:\/\/www.cbs.gov.il\/Accessed January 8 2017."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12256"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.73"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-1645"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-734798"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712803833173"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1515\/hmbci-2015-0016","article-title":"Adiponectin as a biomarker linking obesity and adiposopathy to hematologic malignancies","volume":"23","author":"Dalamaga M","year":"2015","journal-title":"Horm Mol Biol Clin Investig"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-13-17"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15248"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.12.018"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0285"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20079"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.21863","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.21863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T03:17:08Z","timestamp":1719199028000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.21863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,12]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/oby.21863"],"URL":"https:\/\/doi.org\/10.1002\/oby.21863","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,12]]},"assertion":[{"value":"2017-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}