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Association analyses of 74 obesity\u2010related traits and exonic variants were performed using SeqMeta software. Rare autosomal variants were analyzed using gene\u2010based association analyses, and common autosomal variants were analyzed at the SNV level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(1) Rare exonic variants in 10 genes and 16 common SNVs in 11 genes that were associated with obesity traits in a cohort of Hispanic children were identified, (2) novel rare variants in peroxisome biogenesis factor 1 (<jats:italic>PEX1<\/jats:italic>) associated with several obesity traits (weight, weight <jats:italic>z<\/jats:italic> score, BMI, BMI <jats:italic>z<\/jats:italic> score, waist circumference, fat mass, trunk fat mass) were discovered, and (3) previously reported SNVs associated with childhood obesity were replicated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Convergence of whole exome sequencing, a family\u2010based design, and extensive phenotyping discovered novel rare and common variants associated with childhood obesity. Linking <jats:italic>PEX1<\/jats:italic> to obesity phenotypes poses a novel mechanism of peroxisomal biogenesis and metabolism underlying the development of childhood obesity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21869","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T05:46:59Z","timestamp":1494913619000},"page":"1270-1276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Exome sequencing reveals novel genetic loci influencing obesity\u2010related traits in Hispanic children"],"prefix":"10.1002","volume":"25","author":[{"given":"Aniko","family":"Sabo","sequence":"first","affiliation":[{"name":"Human Genome Sequencing Center Baylor College of Medicine Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Mishra","sequence":"additional","affiliation":[{"name":"Human Genome Sequencing Center Baylor College of Medicine Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Dugan\u2010Perez","sequence":"additional","affiliation":[{"name":"Human Genome Sequencing Center Baylor College of Medicine Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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