{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T06:57:21Z","timestamp":1776322641313,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000901","name":"JDRF","doi-asserted-by":"publisher","award":["17\u20102013\u2010313"],"award-info":[{"award-number":["17\u20102013\u2010313"]}],"id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the association between pericardial adipose tissue (PAT) and the ratio of PAT to subcutaneous adipose tissue (SAT) with insulin resistance in adults with and without type 1 diabetes (T1D).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data for this report came from a substudy of the Coronary Artery Calcification in Type 1 Diabetes cohort (<jats:italic>n<\/jats:italic>\u2009=\u200983; 38 with T1D, 45 without T1D). Insulin resistance was measured by hyperinsulinemic\u2010euglycemic clamp. Abdominal computed tomography (CT) was used to measure visceral adipose tissue (VAT) and SAT. PAT was measured from CT scans of the heart.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PAT and the ratio of PAT to SAT was higher in males compared to females. After adjustment for demographics, diabetes, blood pressure and lipid factors, BMI, VAT, and log PAT\/SAT ratio, log PAT was positively associated with the glucose infusion rate (GIR) in females only (\u03b2\u2009=\u20093.36\u2009\u00b1\u20091.96, <jats:italic>P\u2009<\/jats:italic>=\u20090.097, <jats:italic>P<\/jats:italic> for sex interaction\u2009=\u20090.055). Conversely, the log PAT\/SAT ratio was significantly associated with decreased GIR in both males and females (\u03b2\u2009=<jats:italic>\u2009<\/jats:italic>\u22122.08\u2009\u00b1\u20091.03, <jats:italic>P<\/jats:italic>\u2009=\u20090.047, <jats:italic>P<\/jats:italic> for sex interaction\u2009=\u20090.768).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A significant association between the PAT\/SAT ratio and insulin resistance was found, independent of BMI, VAT, and PAT. These results highlight the importance of considering fat distribution independent of volume.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21875","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T16:12:43Z","timestamp":1496160763000},"page":"1284-1291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The ratio of pericardial to subcutaneous adipose tissues is associated with insulin resistance"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3609-2595","authenticated-orcid":false,"given":"Amy C.","family":"Alman","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health University of South Florida Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Translational Research Institute for Metabolism and Diabetes, Florida Hospital Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Eckel","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine University of Colorado Denver Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Hokanson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Colorado School of Public Health University of Colorado Denver Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brant R.","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Microbiology and Molecular Biology, College of Liberal Arts and Sciences University of South Florida Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preethi 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