{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:07:41Z","timestamp":1784333261159,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T00:00:00Z","timestamp":1503878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Tianjin Women's and Children's Health Center"},{"name":"National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health","award":["R01DK100790"],"award-info":[{"award-number":["R01DK100790"]}]},{"name":"National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health","award":["U01DK094418"],"award-info":[{"award-number":["U01DK094418"]}]},{"name":"National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health","award":["R01DK099175"],"award-info":[{"award-number":["R01DK099175"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Gestational weight gain (GWG) is associated with infant birth weight and childhood obesity; however, the patterns of GWG on infant birth weight are poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This analysis in 16,218 mother\u2010child dyads from Tianjin, China, determined the risk of infant size at birth according to GWG occurring throughout the first and second trimester (early GWG) or during the third trimester (late GWG), according to maternal prepregnancy BMI and the 2009 Institute of Medicine recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Excessive GWG in early and late pregnancy had an increased risk for large\u2010for\u2010gestational\u2010age (LGA) infants (odds ratio [OR]: 2.4; 95% confidence interval [CI]: 1.5\u20104.0, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Regardless of prepregnancy BMI, excessive GWG early in pregnancy (&lt;\u200924 weeks) was associated with an increased risk of LGA infants (OR: 2.5; 95% CI: 2.1\u20103.1, <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001), and inadequate early GWG was associated with a higher risk of small\u2010for\u2010gestational\u2010age (SGA) infants (OR: 1.4; 95% CI: 1.2\u20101.7, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The pattern of GWG early in pregnancy, regardless of GWG later in pregnancy, had the greatest impact on infant size at birth. Interventions initiated early in pregnancy may facilitate better adherence to the GWG guidelines and minimize the risk of LGA and SGA infants, a potential precursor for childhood obesity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21878","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T09:21:33Z","timestamp":1504171293000},"page":"1569-1576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Early Pregnancy Weight Gain Exerts the Strongest Effect on Birth Weight, Posing a Critical Time to Prevent Childhood Obesity"],"prefix":"10.1002","volume":"25","author":[{"given":"Nicholas T.","family":"Broskey","sequence":"first","affiliation":[{"name":"Pennington Biomedical Research Center Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Women's and Children's Health Center Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Women's and Children's Health Center Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhong","family":"Leng","sequence":"additional","affiliation":[{"name":"Tianjin Women's and Children's Health Center Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqin","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Women's and Children's Health Center Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leishen","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Women's and Children's Health Center Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Anne","family":"Gilmore","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Hu","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne M.","family":"Redman","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,28]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Weight Gain During Pregnancy: Reexamining the Guidelines","author":"Rasmussen KM","year":"2009"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082310"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.621"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.02.004"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.22506"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21222"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21006"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31829a3b86"},{"key":"e_1_2_5_10_1","unstructured":"Tianjin Women's and Children's Health Center.2010 Tianjin Women and Children Health Care Report."},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077809"},{"key":"e_1_2_5_12_1","first-page":"1","article-title":"Guidelines for prevention and control of overweight and obesity in Chinese adults","volume":"26","author":"Working Group on Obesity in China","year":"2004","journal-title":"Ying Yang Xue Bao"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-11-62"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.005306"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.638953"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2014.57.6.442"},{"key":"e_1_2_5_18_1","first-page":"2881","article-title":"Inadequate gestational weight gain and adverse pregnancy outcomes among normal weight women in China","volume":"8","author":"Wen T","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-015-1760-8"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.22"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.145"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/17477166.2010.521560"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.906081"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-148"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20831"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198802253180801"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.6.1078"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.024307"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2011.07.013"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.21878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.21878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:50:41Z","timestamp":1696348241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.21878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,28]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1002\/oby.21878"],"URL":"https:\/\/doi.org\/10.1002\/oby.21878","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,28]]},"assertion":[{"value":"2017-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}