{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:24:24Z","timestamp":1783441464632,"version":"3.54.6"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Innovation and Science Ministry (Health Institute Carlos III) and the European Fund for Regional Development in Madrid, Spain","award":["PI15\/01078"],"award-info":[{"award-number":["PI15\/01078"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Hepato\u2010visceral fat excess is a feature of polycystic ovary syndrome (PCOS). Risk factors for such excess include low prenatal weight gain and high postnatal weight gain. This study examined whether adolescent PCOS was preceded by a relatively low birth weight and\/or a relatively high BMI at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Study participants included 467 girls with PCOS (298 without obesity and 169 with obesity), diagnosed, respectively, in Spain and Germany; 87 healthy girls were controls. <jats:italic>Z<\/jats:italic> scores for weight at birth and BMI at PCOS diagnosis were derived, and their differences were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Spanish girls with PCOS and without obesity and German girls with PCOS and obesity had mean birth weight <jats:italic>z<\/jats:italic> scores of \u22120.7 and 0.0, respectively, and mean BMI <jats:italic>z<\/jats:italic> scores of\u2009+\u20090.4 and +2.7, respectively, so that mean <jats:italic>z<\/jats:italic> score increments amounted to +1.1 and +2.6 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 vs. controls).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PCOS in adolescent girls was preceded by marked <jats:italic>z<\/jats:italic> score increments between weight at birth and BMI at PCOS diagnosis, thus corroborating the notion that PCOS development is driven by a mismatch between prenatal weight gain and postnatal weight gain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21935","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T11:36:47Z","timestamp":1500896207000},"page":"1486-1489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Reduced Prenatal Weight Gain and\/or Augmented Postnatal Weight Gain Precedes Polycystic Ovary Syndrome in Adolescent Girls"],"prefix":"10.1002","volume":"25","author":[{"given":"Francis","family":"de Zegher","sequence":"first","affiliation":[{"name":"Department of Development and Regeneration University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Reinehr","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Diabetes, and Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten\/Herdecke Datteln Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Malpique","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u, University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyza","family":"Darendeliler","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetes Istanbul Faculty of Medicine, University of Istanbul Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"L\u00f3pez\u2010Bermejo","sequence":"additional","affiliation":[{"name":"Dr. Josep Trueta Hospital and Girona Institute for Biomedical Research Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4595-7191","authenticated-orcid":false,"given":"Lourdes","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u, University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1609"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der229"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1382"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2017.04.010"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011035"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12053"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.01.042"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1849"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3285"},{"key":"e_1_2_5_11_1","unstructured":"McDowellMA FryarCD OgdenCL.Anthropometric reference data for children and adults: United States 1988\u20101994. 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