{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:33:18Z","timestamp":1759336398659,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T00:00:00Z","timestamp":1503187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01MH108148","R01EB015611","R01MH112180","P50MH103222","R01DA027680","R01MH085646","P30DK072488","T32MH067533"],"award-info":[{"award-number":["U01MH108148","R01EB015611","R01MH112180","P50MH103222","R01DA027680","R01MH085646","P30DK072488","T32MH067533"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the association between peripheral lipid\/fat profiles and cerebral gray matter (GM) and white matter (WM) in healthy Old Order Amish (OOA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood lipids, abdominal adiposity, liver lipid contents, and cerebral microstructure were assessed in OOA (<jats:italic>N<\/jats:italic>\u2009=\u200964, 31 males\/33 females, ages 18\u201077). Orthogonal factors were extracted from lipid and imaging adiposity measures. GM assessment used the Human Connectome Project protocol to measure whole\u2010brain average cortical thickness. Diffusion\u2010weighted imaging was used to derive WM fractional anisotropy and kurtosis anisotropy measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lipid\/fat measures were captured by three orthogonal factors explaining 80% of the variance. Factor one loaded on cholesterol and\/or low\u2010density lipoprotein cholesterol measurements; factor two loaded on triglyceride\/liver measurements; and factor three loaded on abdominal fat measurements. A two\u2010stage regression including age\/sex (first stage) and the three factors (second stage) examined the peripheral lipid\/fat effects. Factors two and three significantly contributed to WM measures after Bonferroni corrections (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.007). No factor significantly contributed to GM. Blood pressure (BP) inclusion did not meaningfully alter the lipid\/fat\u2010WM relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Peripheral lipid\/fat indicators were significantly and negatively associated with cerebral WM rather than with GM, independent of age and BP level. Dissecting the fat\/lipid components contributing to different brain imaging parameters may open a new understanding of the body\u2010brain connection through lipid metabolism.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21946","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T04:36:44Z","timestamp":1503290204000},"page":"1876-1880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lipid Metabolism, Abdominal Adiposity, and Cerebral Health in the Amish"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3822-423X","authenticated-orcid":false,"given":"Meghann","family":"Ryan","sequence":"first","affiliation":[{"name":"Maryland Psychiatric Research Center Department of Psychiatry, University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3656-4281","authenticated-orcid":false,"given":"Peter","family":"Kochunov","sequence":"additional","affiliation":[{"name":"Maryland Psychiatric Research Center Department of Psychiatry, University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M.","family":"Rowland","sequence":"additional","affiliation":[{"name":"Maryland Psychiatric Research Center Department of Psychiatry, University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Braxton D.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Maryland School of Medicine Baltimore Maryland USA"},{"name":"Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Andrea","family":"Wijtenburg","sequence":"additional","affiliation":[{"name":"Maryland Psychiatric Research Center Department of Psychiatry, University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Els","family":"Fieremans","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging Department of Radiology, New York University School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelle","family":"Veraart","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging Department of Radiology, New York University School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry S.","family":"Novikov","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging Department of Radiology, New York University School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Du","sequence":"additional","affiliation":[{"name":"Maryland Psychiatric Research Center Department of Psychiatry, University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhim","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Maryland Psychiatric Research Center Department of Psychiatry, University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feven","family":"Fisseha","sequence":"additional","affiliation":[{"name":"Maryland Psychiatric Research Center Department of Psychiatry, University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Bruce","sequence":"additional","affiliation":[{"name":"Maryland Psychiatric Research Center Department of Psychiatry, University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Chiappelli","sequence":"additional","affiliation":[{"name":"Maryland Psychiatric Research Center Department of Psychiatry, University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemalatha","family":"Sampath","sequence":"additional","affiliation":[{"name":"Maryland Psychiatric Research Center Department of Psychiatry, University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth","family":"Ament","sequence":"additional","affiliation":[{"name":"Maryland Psychiatric Research Center Department of Psychiatry, University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan R.","family":"Shuldiner","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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