{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:15:32Z","timestamp":1782738932907,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,2]],"date-time":"2017-09-02T00:00:00Z","timestamp":1504310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["586660"],"award-info":[{"award-number":["586660"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Because sympathetic nervous system activity plays a detrimental role in metabolic and cardiovascular health, this study compared the effects of a centrally acting sympatholytic agent, the effects of a weight loss (WL) program using a low\u2010calorie diet, and the effects of a combination of both.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Young (18\u201030 years) male subjects with overweight (BMI\u2009&gt;\u200925 kg\/m<jats:sup>2<\/jats:sup>) were allocated to a WL program (<jats:italic>n<\/jats:italic>\u2009=\u200910), a moxonidine treatment course (M; <jats:italic>n<\/jats:italic>\u2009=\u200910, 0.4 mg\/d), a combination of both (WL\u2009+\u2009M; <jats:italic>n<\/jats:italic>\u2009=\u200911), or to a control (C) group (<jats:italic>n<\/jats:italic>\u2009=\u20096) for 6 months. Muscle sympathetic nerve activity (MSNA), endothelial function, renal function (Cockcroft\u2010Gault formula), and the metabolic profile were assessed before and after intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>WL occurred in the WL and WL\u2009+\u2009M groups (\u22127.6\u2009\u00b1\u20091.9 kg, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 in both). MSNA and systolic blood pressure decreased similarly in the WL, M, and WL\u2009+\u2009M groups (by \u223c10 bursts\/min, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, and by \u223c9 mm\u2009Hg, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). All other parameters for the WL, C, and M groups remained unchanged. In the WL\u2009+\u2009M group, decreased total cholesterol (\u22120.78\u2009\u00b1\u20090.23 mmol\/L, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), decreased low\u2010density lipoprotein cholesterol (\u22120.49\u2009\u00b1\u20090.16 mmol\/L, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), decreased insulin (\u22126.5\u2009\u00b1\u20092.8 mmol\/L, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and attenuated glomerular hyperfiltration (\u221219\u2009\u00b1\u20095\u2009mL\/min, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of moxonidine with a WL program has beneficial effects on aspects of the metabolic profile and end organ damage in young males with overweight.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.21962","type":"journal-article","created":{"date-parts":[[2017,9,2]],"date-time":"2017-09-02T06:23:13Z","timestamp":1504333393000},"page":"1894-1902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of Moxonidine and Low\u2010Calorie Diet: Cardiometabolic Benefits from Combination of Both Therapies"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2232-9048","authenticated-orcid":false,"given":"Elisabeth A.","family":"Lambert","sequence":"first","affiliation":[{"name":"Human Neurotransmitters Laboratory, Baker Heart and Diabetes Institute Melbourne Victoria Australia"},{"name":"Faculty of Health, Arts and Design Iverson Health Innovation Research Institute, Swinburne University of Technology Hawthorn Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina 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