{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:46:24Z","timestamp":1788878784113,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Prevention of colorectal cancer (CRC) by colonoscopy is recommended according to age and personal\/familial history. Metabolic alterations are associated with colorectal adenomas, but data are scarce regarding serrated polyps and advanced polyps. The aim of this study was to evaluate the association between metabolic alterations and colorectal polyp type and advanced polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2010control study was conducted among consecutive subjects, 40 to 70 years old, who underwent screening\/diagnostic colonoscopy from 2010 to 2015. Subjects who were treated for diabetes, who had a family\/personal history of CRC, and who were at high risk for CRC were excluded. Participants underwent anthropometric, laboratory, and ultrasonographic evaluations and a medical and lifestyle interview. Polyps were histologically classified as adenomatous or serrated polyps and divided into advanced and non\u2010advanced categories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 828 participants (58.4\u2009\u00b1\u20096.6 years, 50.4% men). Abdominal obesity (odds ratio [OR]\u2009=\u20091.67, 95% CI: 1.20\u20102.30), hypertension (OR\u2009=\u20091.47, 95% CI: 1.03\u20102.09), and a high glycosylated hemoglobin percentage (HbA1c%) (OR\u2009=\u20091.57, 95% CI: 1.06\u20102.34) were independently associated with colorectal adenomas, whereas a high triglyceride to high\u2010density lipoprotein cholesterol (TG\/HDL) ratio was independently associated with serrated polyps (OR\u2009=\u20092.31, 95% CI: 1.32\u20104.03). A combination of three metabolic alterations was strongly associated with colorectal polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abdominal obesity, hypertension, and a high HbA1c% are independently associated with adenomas, whereas a high TG\/HDL ratio is associated with serrated polyps. These parameters are easily accessible in clinical practice and may help define high\u2010risk groups for CRC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22001","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T05:35:12Z","timestamp":1509428112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Distinct Metabolic Profiles are Associated with Colorectal Adenomas and Serrated Polyps"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4849-0291","authenticated-orcid":false,"given":"Naomi","family":"Fliss\u2010Isakov","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shira","family":"Zelber\u2010Sagi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Department of Nutrition, Health and Behavior, School of Public Health University of Haifa Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zamir","family":"Halpern","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Shibolet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revital","family":"Kariv","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24216"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.151125"},{"key":"e_1_2_6_4_1","first-page":"207","article-title":"Colonoscopy surveillance: guidelines for polyps and IBD","volume":"62","author":"Senore C","year":"2016","journal-title":"Minerva Gastroenterol Dietol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.73"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1100370"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.02.040"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21336"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.01.033"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2014-0043"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13031"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.381"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-15-0400"},{"key":"e_1_2_6_14_1","first-page":"2211","article-title":"Association of liver steatosis with colorectal cancer and adenoma in patients with metabolic syndrome","volume":"35","author":"Fiori E","year":"2015","journal-title":"Anticancer Res"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3322\/CA.2007.0018"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.001"},{"key":"e_1_2_6_17_1","first-page":"17","article-title":"Population in Israel, by marital status, sex and age, aged 15\u201054, 1987","volume":"40","author":"Central Bureau of Statistics, Israel","year":"1989","journal-title":"Mon Bull Stat U N Stat Off"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-48"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.014"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-9033"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3944-1"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.4016"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2008.01.008"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-10-51"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12055"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28872"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-0772-5"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws157"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws282"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2013.204"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/637538"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.10.022"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318207f3cf"},{"key":"e_1_2_6_34_1","first-page":"163","article-title":"Association between serum HbA1c levels and adenomatous polyps in patients with the type 2 diabetes mellitus","volume":"40","author":"Huang X","year":"2015","journal-title":"Minerva Endocrinol"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm135"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12289"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2014.03.007"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgn171"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140714700"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77812"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2009.02.014"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.22001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.22001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.22001","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.22001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T18:13:57Z","timestamp":1693419237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.22001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,31]]},"references-count":40,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/oby.22001"],"URL":"https:\/\/doi.org\/10.1002\/oby.22001","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,31]]},"assertion":[{"value":"2017-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}