{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:43:22Z","timestamp":1740149002186,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471017"],"award-info":[{"award-number":["81471017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Abnormal fat metabolism is a major disorder in adults who were small for gestational age (SGA). Peroxisome prolferator\u2010activated receptor (PPAR\u03b3) participates in adipocyte differentiation and the regulation of lipid metabolism. This study explored the role of PPAR\u03b3 in the regulation of fat catch\u2010up growth (CUG) and the lipid metabolism of SGA individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The CUG\u2010SGA rats were treated with pioglitazone. The weight of the visceral adipose tissue, serum lipid levels, and PPAR\u03b3 expression in the visceral adipose tissue were detected at 4, 8, and 12 weeks of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PPAR\u03b3 expression in the visceral adipose tissue in the CUG\u2010SGA group was lower than that in the appropriate for gestational age (AGA) group at 4, 8, and 12 weeks (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The serum triglycerides in the CUG\u2010SGA group were elevated compared with that in the AGA group at 4 and 12 weeks (<jats:italic>P<\/jats:italic>\u2009=\u20090.005; <jats:italic>P<\/jats:italic>\u2009=\u20090.037); however, they were significantly decreased after 8 weeks of pioglitazone intervention (<jats:italic>P<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PPAR\u03b3 expression in the visceral adipose tissue was lower in SGA rats and may be related to the regulation of adipocyte differentiation. The early increased PPAR\u03b3 expression by pioglitazone might reduce serum triglycerides and decrease the CUG of the visceral adipose tissue in SGA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22030","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T17:42:44Z","timestamp":1507743764000},"page":"88-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of Peroxisome Proliferator\u2010Activated Receptor (PPAR\u03b3) in Metabolic Disorders in SGA with Catch\u2010Up Growth"],"prefix":"10.1002","volume":"26","author":[{"given":"Qiong\u2010Xia","family":"Lian","sequence":"first","affiliation":[{"name":"Department of Pediatrics the Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Zhu","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics the Third 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