{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:42:00Z","timestamp":1761964920910,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T00:00:00Z","timestamp":1510531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Program UNAM-DGAPA-PAPIIT under","award":["IN200817"],"award-info":[{"award-number":["IN200817"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to compare cortex thickness and neuronal cell density in postmortem brain tissue from people with overweight or obesity and normal weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cortex thickness and neuron density of eight donors with overweight or obesity (mean\u2009=\u200931.6 kg\/m<jats:sup>2<\/jats:sup>; SD\u2009=\u20094.35; <jats:italic>n<\/jats:italic>\u2009=\u20098; 6 male) and eight donors with normal weight (mean\u2009=\u200921.8 kg\/m<jats:sup>2<\/jats:sup>; SD\u2009=\u20091.5; <jats:italic>n<\/jats:italic>\u2009=\u20098; 5 male) were compared. All participants were Mexican and lived in Mexico City. Randomly selected thickness measures of different cortex areas from the frontal and temporal lobes were analyzed based on high\u2010resolution real\u2010size photographs. A histological analysis of systematic\u2010random fields was used to quantify the number of neurons in postmortem left and right of the first, second, and third gyri of frontal and temporal lobe brain samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistical difference was found in cortical thickness between donors with overweight or obesity and individuals with normal weight. A smaller number of neurons was found among the donors with overweight or obesity than the donors with normal weight at different frontal and temporal areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A lower density of neurons is associated with overweight or obesity. The morphological basis for structural brain changes in obesity requires further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22036","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T13:52:42Z","timestamp":1510581162000},"page":"94-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Postmortem Study of Frontal and Temporal Gyri Thickness and Cell Number in Human Obesity"],"prefix":"10.1002","volume":"26","author":[{"given":"Erick","family":"G\u00f3mez\u2010Apo","sequence":"first","affiliation":[{"name":"Neuroscience Project, Faculty of Higher Studies Iztacala National Autonomous University of Mexico Mexico City Mexico"},{"name":"General Hospital of Mexico Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri\u00e1n","family":"Garc\u00eda\u2010Sierra","sequence":"additional","affiliation":[{"name":"Department of Speech, Language and Hearing Sciences University of Connecticut Storrs Connecticut USA"},{"name":"Institute for Collaboration on Health, Intervention, and Policy University of Connecticut Storrs Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Silva\u2010Pereyra","sequence":"additional","affiliation":[{"name":"Neuroscience Project, Faculty of Higher Studies Iztacala National Autonomous University of Mexico Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virgilia","family":"Soto\u2010Abraham","sequence":"additional","affiliation":[{"name":"General Hospital of Mexico Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0557-0163","authenticated-orcid":false,"given":"Alejandra","family":"Mondrag\u00f3n\u2010Maya","sequence":"additional","affiliation":[{"name":"Neuroscience Project, Faculty of Higher Studies Iztacala National Autonomous University of Mexico Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Velasco\u2010Vales","sequence":"additional","affiliation":[{"name":"General Hospital of Mexico Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda S.","family":"Pescatello","sequence":"additional","affiliation":[{"name":"Institute for Collaboration on Health, Intervention, and Policy University of Connecticut Storrs Connecticut USA"},{"name":"Department of Kinesiology University of Connecticut Storrs Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,13]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Obesity and overweight.World Health Organization website.http:\/\/www.who.int\/mediacentre\/factsheets\/fs311\/en\/. 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