{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T11:52:15Z","timestamp":1759837935522,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 A T004094"],"award-info":[{"award-number":["T32 A T004094"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003769","name":"Eisai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study evaluated the effect of lorcaserin 10 mg twice daily (LOR BID), or with phentermine 15 mg once daily (LOR BID\u2009+\u2009PHEN QD) and 15 mg twice daily (LOR BID\u2009+\u2009PHEN BID), in conjunction with energy restriction on food cravings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and thirty\u2010five patients without diabetes but with obesity or overweight and\u2009\u2265\u20091 comorbidity received LOR BID, LOR BID\u2009+\u2009PHEN QD, or LOR BID\u2009+\u2009PHEN BID for 12 weeks in a randomized double\u2010blind study. The Food Craving Inventory (FCI) and the Control of Eating Questionnaire (COEQ) were administered over 12 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The FCI total score and the subscale scores reduced from baseline in all groups. The least squares means (95% confidence intervals) for the total scores were \u22120.65 (\u22120.75 to \u22120.55), \u22120.75 (\u22120.84 to \u22120.65), and \u22120.84 (\u22120.95 to \u22120.74) in the LOR BID, LOR BID\u2009+\u2009PHEN QD, and LOR BID\u2009+\u2009PHEN BID groups, respectively. Cravings assessed by COEQ reduced from baseline in all groups. In general, the combination treatments were more effective than lorcaserin alone. At week 12, except for fruit juice and dairy products, general and specific cravings reduced in LOR BID\u2009+\u2009PHEN BID compared with LOR BID (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lorcaserin in combination with phentermine improves control of food cravings during short\u2010term energy restriction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22094","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T05:15:39Z","timestamp":1516770939000},"page":"332-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of Lorcaserin Alone and in Combination with Phentermine on Food Cravings After 12\u2010Week Treatment: A Randomized Substudy"],"prefix":"10.1002","volume":"26","author":[{"given":"Candida J.","family":"Rebello","sequence":"first","affiliation":[{"name":"Pennington Biomedical Research Center Louisiana State University System Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena V.","family":"Nikonova","sequence":"additional","affiliation":[{"name":"Eisai Medical and Scientific Affairs, Eisai Inc. 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Timothy","family":"Garvey","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences University of Alabama at Birmingham Birmingham Alabama USA"},{"name":"Birmingham VA Medical Center Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Center for the Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute Orlando Florida USA"},{"name":"Translational Research Institute for Metabolism and Diabetes, Florida Hospital Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann A.","family":"Coulter","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center Louisiana State University System Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1766-6111","authenticated-orcid":false,"given":"Frank 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