{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T12:38:09Z","timestamp":1771591089781,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T00:00:00Z","timestamp":1518220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01\u2010DK\u2010100302"],"award-info":[{"award-number":["R01\u2010DK\u2010100302"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01\u2010DK\u2010061628"],"award-info":[{"award-number":["R01\u2010DK\u2010061628"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Limited studies have assessed the relationship between longitudinal changes in adiposity and changes in multiple adipokines over time. This study examined changes in BMI, total body fat, and trunk fat associated with changes in 16 circulating adipokines in Mexican Americans at risk for type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants included 1,213 individuals with cross\u2010sectional data and a subset of 368 individuals with follow\u2010up measures (mean 4.6\u2009\u00b1\u20091.5 years from baseline). Joint multivariate associations between 3 adiposity measures and 16 adipokines were assessed by canonical correlation analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Longitudinal increases in adiposity were most strongly associated with increasing leptin, C\u2010reactive protein (CRP), and interleukin 1 receptor antagonist (IL\u20101Ra) and decreasing adiponectin and secreted frizzled protein 5 (SFRP5) over time. Participants with BMI\u2009\u2265\u200930 kg\/m<jats:sup>2<\/jats:sup> at baseline had greater increases in leptin, CRP, IL\u20101Ra, and interleukin 6 (IL\u20106) and greater decreases in adiponectin and SFRP5, associated with increasing adiposity over follow\u2010up, than those with BMI\u2009&lt;\u200930 kg\/m<jats:sup>2<\/jats:sup>. Associations between adiposity and adipokines were most accounted for by leptin; adjustment for leptin greatly reduced the magnitude of all associations between adiposity and remaining adipokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increasing adiposity contributes to a worsening imbalance of pro\u2010 and anti\u2010inflammatory adipokines over time, in which leptin may have an important role as a key mediator of metabolic disease risk in Mexican Americans.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22128","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T08:12:43Z","timestamp":1518250363000},"page":"703-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Longitudinal Increases in Adiposity Contribute to Worsening Adipokine Profile over Time in Mexican Americans"],"prefix":"10.1002","volume":"26","author":[{"given":"Mary Helen","family":"Black","sequence":"first","affiliation":[{"name":"Department of Research and Evaluation Kaiser Permanente Southern California Pasadena California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Hsiang","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation Kaiser Permanente Southern California Pasadena California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation Kaiser Permanente Southern California Pasadena California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8274-0309","authenticated-orcid":false,"given":"Corinna","family":"Koebnick","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation Kaiser Permanente Southern California Pasadena California 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