{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:23:09Z","timestamp":1789611789741,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T00:00:00Z","timestamp":1529625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56 DK078645"],"award-info":[{"award-number":["R56 DK078645"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK078645"],"award-info":[{"award-number":["R01 DK078645"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001082"],"award-info":[{"award-number":["UL1 TR001082"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Maternal obesity (OB) accounts for the majority of large\u2010for\u2010gestational\u2010age infants, and newborn percent fat (NB%fat) correlates strongest with childhood OB. In addition to maternal glucose, fasting triglycerides (TGs) may contribute, but postprandial triglycerides (PPTGs) are unstudied. It was hypothesized that fasting TGs and PPTGs are higher in women with OB compared with women with normal weight (NW) throughout pregnancy, correlate more strongly with NB%fat than glucose, and may relate to dietary chylomicron TGs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fasting TGs and PPTGs, free fatty acids, glucose, and insulin were prospectively measured 10 times over 4 hours after a controlled liquid breakfast early (14\u201016 weeks) and later (26\u201028 weeks) in pregnancy in 27 mothers with NW and 27 with OB. NB%fat was measured by dual x\u2010ray absorptometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fasting TGs and PPTGs were already\u2009\u2265\u200930% higher in mothers with OB at 14 to 16 weeks (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) versus mothers with NW. In mothers with OB, a simple 1\u2010hour (<jats:italic>r<\/jats:italic>\u2009=\u20090.71;<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) or 2\u2010hour (<jats:italic>r<\/jats:italic>\u2009=\u20090.69;<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) PPTG at 14 to 16 weeks correlated strongest with NB%fat. In mothers with NW, the increase in TGs from early to later pregnancy correlated strongest with NB%fat (<jats:italic>r<\/jats:italic>\u2009=\u20090.57;<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Maternal glucose did not statistically add to prediction models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These novel data suggest that 1\u2010 or 2\u2010hour PPTGs might be a new target for early intervention in pregnancies with OB to prevent excess newborn adiposity and attenuate child OB risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22246","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T08:07:08Z","timestamp":1529654828000},"page":"1347-1356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Postprandial Triglycerides Predict Newborn Fat More Strongly than Glucose in Women with Obesity in Early Pregnancy"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8656-3995","authenticated-orcid":false,"given":"Linda A.","family":"Barbour","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes University of Colorado Anschutz Medical Campus Aurora Colorado USA"},{"name":"Department of Obstetrics and Gynecology, Division of Maternal\u2010Fetal Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah S.","family":"Farabi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob E.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes University of Colorado Anschutz Medical Campus Aurora Colorado USA"},{"name":"Department of Pediatrics, Section of Neonatology University of Colorado Anschutz Medical Campus Aurora Colorado 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Medicine, Division of Endocrinology, Metabolism, and Diabetes University of Colorado Anschutz Medical Campus Aurora Colorado USA"},{"name":"College of Nursing University of Colorado Anschutz Medical Campus Aurora Colorado 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