{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:49:10Z","timestamp":1784922550468,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["T32 DK063929-09"],"award-info":[{"award-number":["T32 DK063929-09"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["U01 DK072493"],"award-info":[{"award-number":["U01 DK072493"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Hypothalamic obesity (HyOb) is a rare cause of rapid weight gain and early metabolic comorbidities. Effective treatment strategies are limited. The registry collected participant data and compared treatment approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The International Registry of Hypothalamic Obesity Disorders (IRHOD) was created as a registry portal to provide education. Data collected from the initial 4 years were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010seven participants were included for analysis (median age: 27 years, range: 3\u201071 years). A total of 96.5% had obesity, and 3.5% had overweight at maximal weight. Seventy\u2010five had brain tumors (86%)\u2014the majority were craniopharyngiomas (72% of those with tumors). Nontumor etiologies included congenital brain malformation (4.6%), traumatic brain injury (3.4%), and genetic anomaly (2.3%). Ninety percent received obesity treatments including nutritional counseling (82%), pharmacotherapy (59%), bariatric surgery (8%), and vagal nerve stimulation (1%). Forty\u2010six percent reported follow\u2010up BMI results after obesity treatment. Surgery was most effective (median BMI decrease: \u22128.2 kg\/m<jats:sup>2<\/jats:sup>, median interval: 2.6 years), with lifestyle intervention (BMI: \u22123.4 kg\/m<jats:sup>2<\/jats:sup>, interval: 1.2 years) and pharmacological therapy (BMI: \u22122.3 kg\/m<jats:sup>2<\/jats:sup>, interval: 0.8 years) being less effective. Eighty percent of participants reporting follow\u2010up weight remained in the obesity range.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IRHOD identified a large cohort with self\u2010reported HyOb. Surgical therapy was most effective at weight reduction. Nutritional counseling and pharmacotherapy modestly improved BMI. Stepwise treatment strategy for HyOb (including nutritional, pharmacological, and surgical therapies in an experienced center) may be most valuable.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22315","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T20:53:11Z","timestamp":1539031991000},"page":"1727-1732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Hypothalamic Obesity: 4 Years of the International Registry of Hypothalamic Obesity Disorders"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1328-1289","authenticated-orcid":false,"given":"Susan R.","family":"Rose","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine Cincinnati Ohio 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