{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:40:41Z","timestamp":1790196041990,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The satiating effect of protein compared with other nutrients has been well described and is thought to be mediated, in part, by gut hormone release. Previously, it has been shown that oral L\u2010arginine acts as a GLP\u20101 secretagogue both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> in rodents. Here, the effect of L\u2010arginine on gut hormone release in humans was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The hypothesis was tested in two separate studies. The first study assessed the tolerability of oral L\u2010arginine in healthy human subjects. The second study assessed the effect of oral L\u2010arginine on gut hormone release following an <jats:italic>ad libitum <\/jats:italic>meal. Subjects were given L\u2010arginine, glycine (control amino acid), or vehicle control in a randomized double\u2010blind fashion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a dose of 17.1 mmol, L\u2010arginine was well tolerated and stimulated the release of plasma GLP\u20101 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and PYY (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) following an <jats:italic>ad libitum<\/jats:italic> meal. Food diaries showed a trend toward lower energy intake and particularly fat intake following L\u2010arginine treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>L\u2010arginine can significantly elevate GLP\u20101 and PYY in healthy human volunteers in combination with a meal. Further work is required to investigate whether L\u2010arginine may have utility in the suppression of appetite and food intake.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22323","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T07:16:30Z","timestamp":1540451790000},"page":"1721-1726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["L\u2010Arginine Increases Postprandial Circulating GLP\u20101 and PYY Levels in Humans"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0416-6505","authenticated-orcid":false,"given":"Anjali","family":"Amin","sequence":"first","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Neophytou","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shermaine","family":"Thein","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh M","family":"Martin","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Alamshah","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Spreckley","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Bloom","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(97)00162-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(96)00024-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(02)00646-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2004.10719381"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32831b9e01"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.1.91"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/52.2.320"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.04.019"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1600782"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511003254"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.5.1246"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.08.001"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1130011"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1380159"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20154"},{"issue":"1","key":"e_1_2_7_17_1","first-page":"R110","article-title":"Intraduodenal infusions of fats elicit satiety in sham\u2010feeding rats","volume":"259","author":"Greenberg D","year":"1990","journal-title":"Am J Physiol"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.5.689"},{"key":"e_1_2_7_19_1","first-page":"18","article-title":"Chemosensory perception in the gut","volume":"14","author":"Hofer D","year":"1999","journal-title":"News Physiol Sci"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2015.00023"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422411000175"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2014.172"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60383-X"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2002685"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665112000134"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.109.055244"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1498-0"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7042101"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1663"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.258947"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1529"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12644"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.223800"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357055957"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91194-9"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90211-2"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2017.09.002"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2017.07.005"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.402677"},{"issue":"1","key":"e_1_2_7_40_1","first-page":"1090.2","article-title":"Expression of putative umami\/L\u2010amino acid receptors in mouse intestine and colon, and a murine enteroendocrine cell line","volume":"31","author":"Wang H","year":"2017","journal-title":"FASEB J"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-306834"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.11.2530"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-2170"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1992.tb01464.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105456"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.1996.9.5.523"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.22323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.22323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.22323","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.22323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T06:30:11Z","timestamp":1694327411000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.22323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,25]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/oby.22323"],"URL":"https:\/\/doi.org\/10.1002\/oby.22323","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,25]]},"assertion":[{"value":"2018-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}