{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:04:39Z","timestamp":1789970679462,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-25195"],"award-info":[{"award-number":["N01-HC-25195"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study examined the longitudinal associations between genetic risk, change in diet quality, and change in visceral adipose tissue (\u0394VAT), abdominal subcutaneous adipose tissue (\u0394SAT), and pericardial adipose tissue (\u0394PAT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1,677 Framingham Heart Study participants who had ectopic fat depots measured using computed tomography were analyzed. Diet quality was quantified using a Mediterranean\u2010style diet score (MDS) and genetic risk by depot\u2010specific genetic risk scores (GRSs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Per SD improvement in MDS, there was 50\u00a0cm<jats:sup>3<\/jats:sup> (95% CI: 14\u201086; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) less fat accumulation in VAT, 52\u00a0cm<jats:sup>3<\/jats:sup> (95% CI: 12\u201092; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) less fat accumulation in SAT, and 1.3\u00a0cm<jats:sup>3<\/jats:sup> (95% CI: 0.1\u20102.4; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) less fat accumulation in PAT. No association was observed between GRSs and \u0394VAT or \u0394SAT. Each 1\u2010SD increase in the PAT GRS was associated with a 1.2\u2010cm<jats:sup>3<\/jats:sup> (95% CI: 0.1\u20102.3; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) increase in \u0394PAT. In participants with higher PAT GRS, those with \u0394MDS \u2265\u00a00 had a favorable change in PAT compared with the counterparts with \u0394MDS &lt;\u00a00 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Longitudinal improvements in diet quality are associated with less ectopic fat accumulation. This study suggests that diet quality may play a critical role in improving ectopic adiposity profiles.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22427","type":"journal-article","created":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T05:45:27Z","timestamp":1551505527000},"page":"670-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Increased Diet Quality is Associated with Long\u2010Term Reduction of Abdominal and Pericardial Fat"],"prefix":"10.1002","volume":"27","author":[{"given":"Rachel","family":"Hennein","sequence":"first","affiliation":[{"name":"Population Sciences Branch National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda Maryland USA"},{"name":"Framingham Heart Study Framingham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Population Sciences Branch National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda Maryland USA"},{"name":"Framingham Heart Study Framingham Massachusetts USA"},{"name":"Department of Biostatistics Boston University Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola M.","family":"McKeown","sequence":"additional","affiliation":[{"name":"Nutritional Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging Tufts University Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Radiology Department Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle T.","family":"Long","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Evans Department of Medicine Boston University School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Levy","sequence":"additional","affiliation":[{"name":"Population Sciences Branch National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda Maryland USA"},{"name":"Framingham Heart Study Framingham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7478-7203","authenticated-orcid":false,"given":"Jiantao","family":"Ma","sequence":"additional","affiliation":[{"name":"Population Sciences Branch National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda Maryland USA"},{"name":"Framingham Heart Study Framingham Massachusetts USA"},{"name":"Nutrition Data Science, Friedman School of Nutrition Science and Policy Tufts University Boston Massachusetts 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