{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:16:21Z","timestamp":1792613781865,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["PCORI CDRN 1306-04681"],"award-info":[{"award-number":["PCORI CDRN 1306-04681"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this work was to study weight loss and risk of cardiovascular disease (CVD) or death associated with longer\u2010term phentermine use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using electronic health record data, 13,972 adults were identified with a first phentermine fill in 2010 to 2015, creating exposure categories according to a patient\u2019s duration of use (referent: \u2264\u20093\u00a0months). Multivariable linear models were used to compare percent weight loss across categories at 6, 12, and 24\u00a0months, and Cox proportional hazards models were used to compare risk of composite CVD or death, up to 3\u00a0years after starting phentermine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort was 84% female and 45% white, with a mean (SD) baseline age 43.5 (10.7)\u00a0years and BMI of 37.8 (7.2)\u00a0kg\/m<jats:sup>2<\/jats:sup>. In multivariable models, longer\u2010term users of phentermine experienced more weight loss; patients using continuously for &gt;\u200912\u00a0months lost 7.4% more than the referent group at 24\u00a0months (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The composite CVD or death outcome was rare (0.3%, 41 events), with no significant difference in hazard ratios between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Greater weight loss without increased risk of incident CVD or death was observed in patients using phentermine monotherapy for longer than 3\u00a0months. Despite the limitations of the observational design, this study supports the effectiveness and safety of longer\u2010term phentermine use for low\u2010risk individuals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22430","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T06:52:40Z","timestamp":1553237560000},"page":"591-602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Safety and Effectiveness of Longer\u2010Term Phentermine Use: Clinical Outcomes from an Electronic Health Record Cohort"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4921-7230","authenticated-orcid":false,"given":"Kristina H.","family":"Lewis","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Prevention, Division of Public Health Sciences Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"},{"name":"Department of Implementation 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Bessesen","sequence":"additional","affiliation":[{"name":"Diabetes &amp; Endocrinology Division Denver Health Medical Center Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew F.","family":"Daley","sequence":"additional","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Desai","sequence":"additional","affiliation":[{"name":"HealthPartners Institute Bloomington Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Center for Health Research Portland Oregon 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